The purpose of this study is to better understand mental illness and will test the hypotheses
that while viewing affective stimuli, patient groups will show increased blood oxygenation
level dependent (BOLD) signal by fMRI after lorazepam.
This study will enroll participants between the ages of 16 and 60, who have a psychotic
illness (such as psychosis which includes conditions like schizophrenia, schizoaffective
disorder, and mood disorders). The study will also enroll eligible participants without any
psychiatric illness, to compare their brains.
The study will require participants to have 3-4 sessions over a few weeks. The initial
assessments (may be over two visits) will include a diagnostic interview and several
questionnaires (qols) to assess eligibility. Subsequently, there will will be two separate
functional magnetic resonance imaging (fMRI) sessions in which lorazepam or placebo will be
given prior to the MRI. During the fMRI the participants will also be asked to answer
questions. Additionally, the participants will have their blood drawn, women of child bearing
potential will have a urine pregnancy test, vital signs taken, and asked to complete more
Please note the collaborator (NIMH) is requesting that an NCT number be obtained prior
to receiving the award number.
Initial assessment(s) may be done via videoconference due to Covid.
Schizophrenia, Bipolar Disorder, Healthy, Psychosis, Schizophreniform Disorders, Schizo Affective Disorder, Major Depression With Psychotic Features
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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