Liposomal Bupivacaine vs Dexamethasone ISB

  • days left to enroll
  • participants needed
  • sponsor
    Hospital for Special Surgery, New York
Updated on 24 February 2022
postoperative pain
shoulder surgery
interscalene brachial plexus block


In this study, patients receiving shoulder arthroscopy will receive an interscalene block for pain management containing either liposomal bupivacaine and standard bupivacaine or standard bupivacaine and dexamethasone. Patients will be followed up with to determine postoperative pain and block duration.

Condition Shoulder Pain
Treatment Dexamethasone, Exparel 133 MG Per 10 ML Injection
Clinical Study IdentifierNCT04047446
SponsorHospital for Special Surgery, New York
Last Modified on24 February 2022


Yes No Not Sure

Inclusion Criteria

Age 18 years or older
Scheduled for elective outpatient arthroscopic shoulder surgery

Exclusion Criteria

History of allergy to local anesthetic, or one of the study medications
Pre-existing neurological deficits
Psychiatric or cognitive disorders that prohibit patients from following study protocol
History of drug or alcohol abuse
Chronic opioid use (longer than 3 months)
Chronic pain syndromes
Infection at the site of injection
Patients with severe pulmonary disease
Herniated cervical disc, cervical myelopathy
Contraindication for general anesthesia and/or interscalene nerve block
Open shoulder arthrotomies
Non English speakers
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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