The Efficacy and Mechanism of DBS in VIC and NAcc for Refractory OCD

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    20
  • sponsor
    Ruijin Hospital
Updated on 23 January 2021
behavior therapy
treatment regimen
antidepressants
antipsychotics
cognitive therapy
brain stimulation
serotonin reuptake inhibitors

Summary

This study will evaluate the efficacy and explore the mechanism of deep brain stimulation (DBS) in the ventral internal capsule (VIC) and nucleus accumbens (NAc) for refractory obsessive-compulsive disorder (OCD).

Details
Condition Obsessive-Compulsive Disorder, Deep Brain Stimulation, ANXIETY NEUROSIS, Anxiety Disorders, Generalized Anxiety Disorder (GAD), Anxiety Disorders (Pediatric), Generalized Anxiety Disorder (GAD - Pediatric), Anxiety Disorders (Pediatric), Generalized Anxiety Disorder (GAD), Generalized Anxiety Disorder (GAD - Pediatric), Anxiety Disorders, obsessive compulsive disorder
Treatment DBS System
Clinical Study IdentifierNCT04228744
SponsorRuijin Hospital
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Diagnosis of OCD with duration of at least 5 years
Severity rated as severe to extreme illness
Failed adequate trial of at least three specific serotonin reuptake inhibitor (SSRI) antidepressants
Failed augmentation with antipsychotic
Completed or failed to complete adequate trial of cognitive behavioural therapy for OCD
Stable medication regimen for one month before surgery
Signed informed consent

Exclusion Criteria

Hoarding as a primary symptom
No other serious psychiatric disorder such as psychotic disorder
Drug or substance use disorder within 6 months except nicotine
Major Neurological/Medical condition
High suicide risk
Pregnancy or lactation
Contraindications to stereotactic surgery
Contraindications to MRI
Clear my responses

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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