CHIEF PD (CHolinesterase Inhibitor to prEvent Falls in Parkinson's Disease)

  • STATUS
    Recruiting
  • End date
    Nov 12, 2022
  • participants needed
    600
  • sponsor
    University of Bristol
Updated on 26 January 2020
dopamine

Summary

Parkinson's disease is a common condition particularly affecting older people. Falls are a very frequent complication of the disease affecting 60% of people with Parkinson's every year. As the population ages, the number of people living with Parkinson's disease and the occurrence of complications will increase. The loss of the chemical dopamine in the brain causes walking in Parkinson's to become slower, unsteady and irregular. People with the condition are therefore at a very high risk of falling. To some extent, people can compensate for these changes by paying more attention to their walking. However, Parkinson's also diminishes memory and thinking ability. This decreases people's ability to pay attention to their walking, especially when doing something at the same time.

Cholinesterase inhibitor (ChEis) are drugs that are currently used to treat people with memory problems in Parkinson's. The effect of these drugs on falls in Parkinson's has been tested to show that treatment has the potential to almost halve the number of falls.

This trial aims to definitively determine whether cholinesterase inhibitors (ChEi), can prevent falls in Parkinson's and whether this treatment is cost effective. 600 participants with Parkinson's disease will be enrolled from hospitals throughout the UK. Participants will be randomly assigned to either receive the drug (ChEi) via a patch or receive a placebo (dummy) treatment via a patch.

Neither the researchers nor the participants will know which group they are in. Participants will take the medication for 12 months and record any falls that they experience in diaries. If successful, this treatment in Parkinson's disease, would tackle one of the most disabling complications of the disease and positive findings will provide robust evidence to change clinical practice.

Details
Treatment Rivastigmine Transdermal System, Placebo Transdermal System
Clinical Study IdentifierNCT04226248
SponsorUniversity of Bristol
Last Modified on26 January 2020

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Eligibility

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Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have Parkinson's disease?
Diagnosis of idiopathic Parkinson's disease
Modified Hoehn and Yahr stage 1-4 disease as determined at baseline visit
Have experienced a fall in the previous year
Able to walk 10m without aids or assistance
+ years of age

Exclusion Criteria

Previous ChEi use in 12 months prior to enrolment
Hypersensitivity to rivastigmine
Dementia diagnosed according to MDS criteria (6)
Inability to attend or comply with treatment or follow-up scheduling
Non-English-speaking patients (cognitive tests performed in English)
Falling 4x per day
Unwillingness to use an acceptable method of contraception for the duration of the trial if they are of childbearing potential
Pregnancy and/or breastfeeding
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