Muscle Capillarization and Sarcopenia

  • End date
    Apr 30, 2022
  • participants needed
  • sponsor
    Baltimore VA Medical Center
Updated on 16 April 2020
Steven J Prior, PhD
Primary Contact
University of Maryland (2.8 mi away) Contact
+1 other location
body mass index
strength training


Aging is associated with a loss of muscle mass, termed sarcopenia, that reduces mobility, decreases physical function and accelerates progression of other age-related disorders. This study is designed to determine whether increasing skeletal muscle capillarization through aerobic exercise will enhance muscular adaptations to strength training in older adults with sarcopenia.


Sarcopenia, or the aging-related loss of muscle mass, affects a large number of older adults. The presence of sarcopenia is associated with physical disability, poor quality of life, and all-cause mortality, in part because sarcopenic adults have low muscle skeletal muscle capillarization and may lack the adequate perfusion needed to maintain muscle mass and function. This study will test the effects of increasing skeletal muscle capillarization through aerobic exercise training on responses to resistance training in older adults. Eligible participants will be randomized to one of two groups, resistance training preceded by aerobic exercise training (AEX-RT), or resistance training followed by aerobic exercise training (RT-AEX). Participants in the AEX-RT group will undergo 3 months of aerobic exercise training to increase skeletal muscle capillarization, followed by 3 months of resistance training. Participants in the RT-AEX group will undergo 3 months of resistance training, followed by 3 months of aerobic exercise training. Before and after the interventions, participants will undergo assessments of muscle size, strength, and capillarization, as well as assessments of physical function.

Treatment Aerobic exercise training, Strength training
Clinical Study IdentifierNCT03984994
SponsorBaltimore VA Medical Center
Last Modified on16 April 2020

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Inclusion Criteria

Is your age between 70 yrs and 88 yrs?
Gender: Male or Female
Do you have Sarcopenia?
Body Mass Index = 18-29.9 kg/m2
Presence of at least moderate sarcopenia (low muscle mass per unit body height)

Exclusion Criteria

Diagnosis of diabetes, cancer, pulmonary or renal disease
Physical impairment preventing exercise
Recent history of exercise training
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