Imaging of Tumour Microenvironment in Patients With Oropharyngeal Head and Neck Squamous Cell Carcinoma Using RGD PET/CT Imaging (PIVOT)

  • End date
    Sep 1, 2023
  • participants needed
  • sponsor
    Radboud University
Updated on 23 February 2022
ct scan
squamous cell carcinoma of the head and neck
human papillomavirus
pet/ct scan
oropharyngeal carcinoma


Known risk factors inducing squamous cell carcinomas of the head and neck are tabacco and alcohol intake. However, the incidence of human papillomavirus (HPV) related oropharyngeal carcinomas is increasing. It is known that HPV+ and HPV- tumors have a different reaction to (chemo)radiotherapy. The exact mechanisms underlying these differences is not yet known but might be caused by changes in vascularity. Therefore the vasculature is imaged with the help of a study specific Gallium-68-DOTA-(RGD)2 PET/CT scan and a CT perfusion scan.


The incidence of Human Papilloma Virus positive (HPV+) oropharyngeal Head and Neck Squamous Cell Carcinoma (HNSCC) is rising and it has become evident that this type of cancer represents a subgroup of HNSCC that is characterized by a more favourable prognosis, mediated by a distinct tumour microenvironment, compared to patients with HPV negative (HPV-) tumours. However, the exact mechanisms underlying this improved treatment outcome and the potential role of the tumour microenvironment are not fully understood yet. Imaging of v3 integrin expression will obtain more insight in the differences in tumour microenvironment between HPV+ and HPV- oropharyngeal HNSCC. CT perfusion provides additional characterisation of this tumour microenvironment. Therefore, these techniques may have the potential to predict response to treatment and might possibly steer treatment decisions in future clinical trials.

Condition Oropharyngeal Squamous Cell Carcinoma
Treatment RGD PET/CT
Clinical Study IdentifierNCT04222543
SponsorRadboud University
Last Modified on23 February 2022


Yes No Not Sure

Inclusion Criteria

Proven squamous cell carcinoma of the oropharynx
p-16 immunohistochemistry analysis
Tumour lesion of at least 1.0 cm in diameter
Planned chemoradiotherapy as primary treatment
Ability to provide written informed consent

Exclusion Criteria

Contra-indications for PET
Contra-indications for administration of iodine-containing contrast agents
Other serious illness that can affect the scans
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