MRI Assessment of Pulmonary Edema in Acute Heart Failure

  • End date
    Jun 1, 2024
  • participants needed
  • sponsor
    University of Alberta
Updated on 10 October 2021
ejection fraction


Researchers are testing a more accurate way to measure how much fluid is in the lungs (also called pulmonary edema, or "increased lung water") in people with Heart Failure (HF) using MRI (Magnetic Resonance Imaging). There is little known about the exact level of lung water in patients with AHF or how these levels change from the time of hospital admission to discharge. The purpose of this research study is to measure the lung water in patients hospitalized for HF, to determine the change in lung water over the course of hospitalization and treatment, and to find out if lung water levels can predict if patients are higher or lower risk for returning to the hospital or dying from heart failure.


Heart failure is a condition where the heart is unable to pump enough blood to meet the body's needs and Acute Heart Failure is a sudden worsening of this condition. It is associated with many symptoms but most commonly includes shortness of breath due to pulmonary edema (or increased "lung water").

A physical exam and chest x-ray are commonly used to diagnose AHF and estimate the amount of increased lung water in patients with AHF. This study will use images from MRI (Magnetic Resonance Imaging) scans to obtain a more accurate measurement of the increased lung water in AHF patients. Lung water will be measured via MRI at hospital admission and discharge to find out the change in lung water over the course of hospitalization and treatment. The investigators will collect NT-proBNP and perform a chest x-ray upon hospital admission and again upon discharge, if not already done as part of usual care. The investigators will follow medical records for one year after hospitalization to see if the accurate lung water measurements obtained in hospital can predict long term outcomes. This is a single-centre project and a total of 300 patients will be recruited to participate.

Condition Pulmonary Edema With Heart Failure, Acute Heart Failure
Treatment MRI
Clinical Study IdentifierNCT03999138
SponsorUniversity of Alberta
Last Modified on10 October 2021


Yes No Not Sure

Inclusion Criteria

years of age or older and willing/able to provide informed consent
patients being treated for acute heart failure (including those patients with both reduced and preserved ejection fraction)
patients receiving medical therapy for pulmonary edema by current standard of care (including oral or IV diuretics)
patients identified within 48 hours of initiation of medical therapy for pulmonary edema, defined as the time of first diuretic (IV or PO) or escalation of existing diuretic therapy administered within the ED or hospital

Exclusion Criteria

contraindication to MRI
patient too critically ill/unstable as per the clinical care team for transport to MRI scanner within the required scanning window
moderate to severe dementia
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