OPTimizing Treatment Focused Genetic Testing IN Cancer (OPT-IN)

  • STATUS
    Recruiting
  • End date
    Dec 31, 2028
  • participants needed
    1200
  • sponsor
    Dana-Farber Cancer Institute
Updated on 2 May 2022

Summary

This two-part randomized controlled trial aims to evaluate the impact of pre-test video education as compared to pre-test Chatbot education.

Description

In this research study, the investigators are introducing the option of two alternatives to genetic counseling before genetic testing: Chatbot and video education.

The first part of this research study is a Pilot Study, which is the first-time investigators are examining the use of a Chatbot to deliver pre-genetic test education. The Chatbot will converse with you about germline genetic testing by text message.

The Pilot study will enroll 200 participants with a metastatic breast or ovarian cancer diagnosis and will assess the uptake of genetic testing among the two possible groups of pre-genetic test counseling.

The second part of this research study will utilize findings from the Pilot Study for 1000 participants with a diagnosis of breast, ovarian, pancreatic or prostate cancer.

In both parts of this research study, participants will be randomized to either the video education or Chatbot. Participants may request in-person genetic counseling after their respective education prior to testing.

Other studies at both DFCI and outside institutions have started to investigate alternative methods of educating patients about genetic testing. These studies have suggested that alternatives to standard genetic counseling may increase access to genetic testing with similar satisfaction to standard of care.

The investigators are hoping to get a sense of participants' preferences for pre genetic test education, understanding, and reactions to the alternative methods of genetic counseling. The investigators are also hoping to understand preferences for communication of their result and whether any treatment changes have been made after they receive their result.

Details
Condition Breast Cancer, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer
Treatment Video Education, Chatbot
Clinical Study IdentifierNCT04066361
SponsorDana-Farber Cancer Institute
Last Modified on2 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult patients over the age of 18
With a diagnosis of advanced cancer (defined as Stage 3 or 4), or
Any stage for pancreatic cancer and
No prior cancer genetic panel testing

Exclusion Criteria

Adults unable to consent
Individuals who are not yet adults (infants, children, teenagers)
Pregnant women (if known at the time of participation)
Prisoners
Non-English speakers
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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