Transcranial Direct Current Stimulation (tDCS) in the Treatment of Drug-na ve Obsessive-compulsive Disorder(OCD)

  • STATUS
    Recruiting
  • days left to enroll
    62
  • participants needed
    60
  • sponsor
    Shanghai Mental Health Center
Updated on 20 September 2021
MRI
transcranial direct current stimulation
transcranial magnetic stimulation

Summary

This study will evaluate the possible therapeutic effects of Transcranial Direct Current Stimulation (tDCS) in drug-nave obsessive-compulsive disorder (OCD) patients, and the underlying neural mechanism by magnetic resonance imaging (MRI),transcranial magnetic stimulation and electroencephalography (TMS-EEG).

Description

The purpose of this study is to examine the efficacy of tDCS over orbitofrontal cortex (OFC) in treatment of drug-nave OCD patients. 60 drug-nave OCD patients will be randomized into two groups (i.e. active or sham stimulation). tDCS stimulation will be performed once a day, five times a week, for two weeks. The investigators will assess symptom severity before and after two weeks of tDCS. Through the study, Yale-Brown Obsessive Compulsive ScaleY-BOCS, the Obsessive Compulsive Inventory-Revised (OCI-R), the Beck Depression Inventory-II (BDI-II), the Beck Anxiety Inventory (BAI), Perceived Stress Scale (PSS), Pittsburgh sleep quality index (PSQI)and side-effect questionnaire will be obtained by a trained investigator. The patients will also receive MRI scan and TMS-EEG.

Details
Condition Generalized Anxiety Disorder (GAD), ANXIETY NEUROSIS, Anxiety Disorders, obsessive compulsive disorder, Anxiety Disorders (Pediatric), Generalized Anxiety Disorder (GAD - Pediatric), Obsessive-Compulsive Disorder
Treatment Sham tDCS, High-Definition Transcranial Direct Current Stimulation
Clinical Study IdentifierNCT04086446
SponsorShanghai Mental Health Center
Last Modified on20 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

age: 18-50 years old
DSM-5 criteria for OCD
Y-BOCS total score > or = 16, discontinued medication for at least 8 weeks before tDCS stimulation
>or9 years education

Exclusion Criteria

Any axis I psychiatric disorder comorbidity
The inability to receive tDCS because of metallic implants, or history of seizuresor 3.history of head injury, or history of neurosurgery
Participants with claustrophobic, heart pacemaker, mechanical heart valve, mechanical implant such as an aneurysm clip, hip replacement, or any other pieces of metal that have accidentally entered their body
Any current significant medical condition
serious suicide risk
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