Denosumab in Treating Patients With Bone Loss Due to Donor Stem Cell Transplant

    Not Recruiting
  • End date
    Aug 19, 2023
  • participants needed
  • sponsor
    Roswell Park Cancer Institute
Updated on 5 March 2022
bone mineral density
dual-energy x-ray absorptiometry
x-ray absorptiometry


This Phase II trial studies the side effects of denosumab and to see how well it works in treating patients with bone loss who have received a donor stem cell transplant. Patients receiving a donor stem cell transplant may experience accelerated bone loss and an increase risk of bone fractures, leading to a decrease in satisfaction and quality of life. A type of immunotherapy drug called denosumab binds to a protein called RANKL, which may help keep bone from breaking down.



I. To evaluate the efficacy and safety of denosumab therapy for the treatment of bone loss in patients who have received an allogeneic hematopoietic stem cell transplant.


Patients receive 2 doses of denosumab subcutaneously (SC) between days 70-130 and days 250-310 after allogeneic hematopoietic stem cell transplant in the absence of disease progression or unacceptable toxicity.

After completion of study treatment patients are followed up at 6 months.

Condition Metabolic Disorders, Osteoporosis, Allogeneic Hematopoietic Stem Cell Transplantation Recipient, bone loss, Metabolic disorder, decreased bone mineral density, Osteopenia, low bone density, Bone Diseases
Treatment Denosumab
Clinical Study IdentifierNCT03925532
SponsorRoswell Park Cancer Institute
Last Modified on5 March 2022

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note