Patient-ventilator Asychrony During Non-invasive Ventilation When COPD Patients Doing Exercise

  • days left to enroll
  • participants needed
  • sponsor
    Guangzhou Medical University
Updated on 2 March 2021
chronic obstructive pulmonary disease


Pulmonary rehabilitation programmes including aerobic exercise training have strong evidence of effectiveness in improving exercise capacity, dyspnoea and HRQL in patients with COPD. Therefore, current guidelines recommend pulmonary rehabilitation, including exercise training, in these patients. Non-invasive ventilation(NIV) is increasingly used during exercise training programmes in order to train patients at intensity levels higher than allowed by their clinical and pathophysiological conditions. Patient-ventilator asynchrony (PVA) describes the poor interaction between the patient and the ventilator and is the consequence of the respiratory muscle activity of the patient being opposed to the action of the ventilator.PVA have unfavourable clinical impace on gas exchange, dyspnoea perception, patient comfort and tolerance and reduced adherence to NIV. This study is going to detect whether the PVA will increase when COPD patients exercise with NIV supporingt

Condition Cryptogenic Organizing Pneumonia, Policeman, Pulmonary Rehabilitation, Non-invasive Ventilation, Non Invasive Ventilation, rehabilitation pulmonary
Clinical Study IdentifierNCT04054622
SponsorGuangzhou Medical University
Last Modified on2 March 2021


Yes No Not Sure

Inclusion Criteria

Age 40-80, males and females
Stage III and IV COPD
Similar with non-invasive ventilation
Willing to participate in the study
Able to provide informed consent

Exclusion Criteria

Presented with an acute exacerbation during previous 3 months
Bronchiectasis; post-tuberculosis sequelae; rib cage deformities; neuromuscular disorders; and bronchial carcinoma
Intolerant with NIV
Clear my responses

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