Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)
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- STATUS
- Recruiting
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- End date
- Oct 4, 2026
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- participants needed
- 1054
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- sponsor
- Amgen
Summary
To evaluate the safety and tolerability of sotorasib administered in investigational regimens in adult participants with KRAS p.G12C mutant advanced solid tumors.
Details
| Condition | Advanced Solid Tumors, Kirsten Rat Sarcoma (KRAS) pG12C Mutation |
|---|---|
| Treatment | Panitumumab, Everolimus, Pembrolizumab, Afatinib, FOLFIRI, Palbociclib, Trametinib, Atezolizumab, Loperamide, FOLFOX, TNO155, PD-1 Inhibitor, AMG 510, RMC-4630, AMG 404, PD1 inhibitor, MEK inhibitor, SHP2 allosteric inhibitor, Pan-ErbB tyrosine kinase inhibitor, Sotorasib, PD-L1 inhibitor, EGFR inhibitor, Chemotherapeutic regimen, mTOR inhibitor, mTOR inhibitor, CDK inhibitor, VEGF inhibitor, VEGF inhibitor, carboplatin, pemetrexed, docetaxel, MVASI® (bevacizumab-awwb) |
| Clinical Study Identifier | NCT04185883 |
| Sponsor | Amgen |
| Last Modified on | 7 October 2022 |
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