Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)

  • End date
    Oct 4, 2026
  • participants needed
  • sponsor
Updated on 7 October 2022


To evaluate the safety and tolerability of sotorasib administered in investigational regimens in adult participants with KRAS p.G12C mutant advanced solid tumors.

Condition Advanced Solid Tumors, Kirsten Rat Sarcoma (KRAS) pG12C Mutation
Treatment Panitumumab, Everolimus, Pembrolizumab, Afatinib, FOLFIRI, Palbociclib, Trametinib, Atezolizumab, Loperamide, FOLFOX, TNO155, PD-1 Inhibitor, AMG 510, RMC-4630, AMG 404, PD1 inhibitor, MEK inhibitor, SHP2 allosteric inhibitor, Pan-ErbB tyrosine kinase inhibitor, Sotorasib, PD-L1 inhibitor, EGFR inhibitor, Chemotherapeutic regimen, mTOR inhibitor, mTOR inhibitor, CDK inhibitor, VEGF inhibitor, VEGF inhibitor, carboplatin, pemetrexed, docetaxel, MVASI® (bevacizumab-awwb)
Clinical Study IdentifierNCT04185883
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Men or women greater than or equal to 18 years old
Pathologically documented, locally-advanced or metastatic malignancy with, KRAS p.G12C mutation identified through molecular testing performed according to in-country requirements. In the United States, this test must be performed in a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory

Exclusion Criteria

Primary brain tumor
Spinal cord compression, or untreated, or symptomatic, or active brain metastases, or leptomeningeal disease from non-brain tumors
Myocardial infarction within 6 months of study day 1
Gastrointestinal (GI) tract disease causing the inability to take oral medication
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note