Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study (CCCA)

  • STATUS
    Recruiting
  • days left to enroll
    67
  • participants needed
    250
  • sponsor
    Wake Forest University Health Sciences
Updated on 8 June 2022

Summary

The objective of this study is to examine photos of CCCA patients taken before and after treatment to compare treatment outcomes between different treatment groups

Description

Treatment groups that patients will be randomized to include 1) topical steroid plus oral antibiotic group, and topical minoxidil after 8 months 2) topical steroid plus intralesional steroid group and topical minoxidil after 8 months. Both these regimens are used as the first-line treatments by clinicians. The objective of this study is to examine photos of CCCA patients taken before and after treatment to compare treatment outcomes between different treatment groups.

In this study, the investigators are looking to determine how standard treatment affects the outcome of central centrifugal cicatricial alopecia; to determine if topical steroid with With Doxycycline has better outcome than topical steroids with intralesional steroids in central centrifugal cicatricial alopecia, and to determine how the addition of topical minoxidil as a treatment changes the outcome of central centrifugal cicatricial alopecia.

Details
Condition Central Centrifugal Cicatricial Alopecia (CCCA)
Treatment triamcinolone acetonide, Minoxidil, Topical steroid class I-II, Doxycyline
Clinical Study IdentifierNCT04207931
SponsorWake Forest University Health Sciences
Last Modified on8 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

African-American women, ages 18-60 years old
with a clinical diagnosis and biopsy-proven CCCA, with Central Scalp Alopecia Scale severity 1 through 4 will be included in this study
These subjects will be seen and treated in Wake Forest Baptist Health Dermatology Outpatient Clinic

Exclusion Criteria

Patients with other forms of hair loss in addition to CCCA will be excluded
Other patients to be excluded are those with other forms of inflammatory scalp disease (with the exception of mild seborrheic dermatitis)
patients who have had topical treatment for CCCA within the past 4 months (including topical steroids, topical minoxidil, or any other topical hair regrowth medication)
patients who have been on a long-term oral antibiotics for hair loss within the past year
patients who have undergone more than two rounds of intralesional steroid injections to the scalp in the past one year
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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