Acute Decompensation of Pulmonary Hypertension

  • days left to enroll
  • participants needed
  • sponsor
    Assistance Publique - Hôpitaux de Paris
Updated on 24 January 2021
diuretic therapy
pulmonary arterial hypertension
chronic thromboembolic pulmonary hypertension


The main objective of this study is to analyze the survival of a cohort of patients admitted for acute decompensation of pulmonary arterial hypertension or postembolic pulmonary hypertension and to establish the prognostic value of biomarkers.


It is planned to include 150 patients over a two-year period. The primary endpoint is a composite endpoint including death, circulatory assistance or emergency transplantation within 90 days following admission to intensive care unit. Patients will be treated according to the usual practice. A biobank will be created from blood samples taken at admission, days 3 and days 7. Prognostic value of pre-selected biomarkers will be analyzed and a proteomic analysis will be performed in order to identify new biomarkers. The prognostic value of these new biological parameters will be compared to the usual monitoring parameters that will be collected during follow-up (clinical, echocardiographic and haemodynamic parameters). In a second step, it will establish, using a dynamic model, the best combinations of parameters allowing to best assessment of prognosis of patients suffering from PH and hospitalized for acute right ventricular failure.

Condition Pulmonary Hypertension, Biological Markers, Cancer Prevention, Surviving Abuse, Joint Injuries, Abdominal Surgery, Mental Disability, Pelvic Adhesions, Low Testosterone, Dental Filling, Habit Reversal, Complicated Grief, Chronic Pelvic Pain, Gambling Problems, Myopic Macular Degeneration, Nerve Injury, Severe Premenstrual Symptom, Stasis Dermatitis, Pulmonary Arterial Hypertension, Open Heart Surgery, Recurrent Pregnancy Loss, Effects of Chemotherapy, Renal Anemia, Functional Dyspepsia, Catheter Complications, Serial Evaluation of Ductal Epithelium, Chronic Renal Anemia, Cancer Treatment, Anemic Cancer, Spinocerebellar Disorders, Pseudobulbar Affect, Spine Athroplasty, Indikation: Diabetes - Typ II, Partial Medial Meniscectomy, Primary Insulin Hypersecretion, Testotoxikose, Infantile Fibrosarcoma, Late Infantile Neuronal Ceroid Lipfuscinsosis, Memory Problems
Treatment A biobank will be created from blood samples taken at admission, days 3 and days 7
Clinical Study IdentifierNCT03926572
SponsorAssistance Publique - Hôpitaux de Paris
Last Modified on24 January 2021


Yes No Not Sure

Inclusion Criteria

Adult patients over 18 years
Diagnosis of Pulmonary arterial hypertension or non-operable chronic thromboembolic pulmonary hypertension established by right cardiac catheterization prior to inclusion in the study
Patients admitted in intensive care unit for acute decompensation of pulmonary hypertension requiring intravenous diuretic therapy use of inotropes or vasopressors
Patients must have given their written informed consent to participate in the study after having received adequate previous information and prior to any study-specific procedures

Exclusion Criteria

Patients with post-capillary pulmonary hypertension
Patients with pulmonary hypertension associated with chronic respiratory disease
Patients with pulmonary hypertension with unclear/or multifactorial mechanisms
Patients with operable chronic thromboembolic pulmonary hypertension
Shock due to another cause than acute decompensation of pulmonary hypertension
Pregnant women, or breast feeding women
Adult protected person
Person deprived of liberty
Person admitted without consent
Pregnant or breastfeeding women
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