Effects of CKI for Oral Mucositis Caused by Radiotherapy for Head and Neck Cancer

  • STATUS
    Recruiting
  • participants needed
    144
  • sponsor
    Shanxi Zhendong Pharmacy Co., Ltd
Updated on 7 February 2023

Summary

Oral mucositis (OM) is an acute side effect of radiotherapy for head and neck cancer (HNC). OM associated pain affects oral functions and nutrition of the patient that may result in discontinuity of treatment.The purpose of this clinical study is to evaluate the therapeutic effects of Compound Kushen Injection (CKI) on oral mucositis caused by radiotherapy of head and neck cancer.

Description

Patients with oral mucositis caused by radiotherapy for Head and Neck Cancerwill be enrolled in the trial, then seprated randomly in two group,the experimental group treated with Levofloxacin injection plus CKI; the contral group treated with Levofloxacin injection only. Clinical grade of radioactive oral mucositisOral pain scoreCompletion and duration of interruption of radiotherapy Completion of chemotherapy during concurrent chemoradiotherapyweight changeFood intake (liquid food, semi liquid food)recovery time of oral mucositis will be compared before treatment, 3 days, 5 days and 7 days after treatment between the experimental group and the control group.

Details
Condition Radiation-induced Oral Mucositis
Treatment Compound Kushen Injection, Levofloxacin injection, Compound Kushen Injection(CKI)
Clinical Study IdentifierNCT04204382
SponsorShanxi Zhendong Pharmacy Co., Ltd
Last Modified on7 February 2023

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