Genetic Mutation in Epithelial Ovarian Cancer

  • STATUS
    Recruiting
  • End date
    Jan 1, 2023
  • participants needed
    500
  • sponsor
    Lei Li
Updated on 23 January 2021
carcinoma
adenocarcinoma
ovarian cancer
platinum-based chemotherapy

Summary

Little is known about the characteristics of genetic mutation in a large multi-gene panel in epithelial ovarian cancer. This study is to explore the targeted genetic mutations via a multi-gene panel, which consists of more than 500 hundred genes. The mutation characteristics are to be revealed in single nucleotide variants, copy number variations, insertion-deletion variations, and genomic structural variations. The total mutation burden (TMB) will be calculated. The status of microsatellite instability, expression of PD-1 and PD-L1 antibodies are also tested. These findings will be studies in association with the patients' prognosis and sensitivity to platinum-based chemotherapy.

Details
Condition Microsatellite Instability, Genomic Structural Variation, Ovarian Epithelial Cancer, Epithelial Ovarian Cancer, Epithelial Ovarian Carcinoma, Nucleotide Variant, Copy Number Variation, Insertion-deletion Variation, Total Mutation Burden, PD-1, PD-L1, ovarian epithelial carcinoma, carcinoma of the ovary, Insertion-deletion Variation, PD-1, PD-L1
Treatment A multi-gene panel testing
Clinical Study IdentifierNCT04191252
SponsorLei Li
Last Modified on23 January 2021

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