Pyrotinib, Dalpiciclib(SHR6390) and Endocrine Therapy in Subjects With Dual-receptor Positive(ER+/HER2+) Advanced Breast Cancer (PLEASURABLE)

  • STATUS
    Recruiting
  • End date
    Dec 12, 2022
  • participants needed
    79
  • sponsor
    Fudan University
Updated on 25 March 2022
estrogen
measurable disease
growth factor
endocrine therapy
progesterone
metastasis
hormone therapy
advanced breast cancer
HER2
trastuzumab
progesterone receptor
fulvestrant
stage iv breast cancer
erbb2
aromatase inhibitor
estrogen receptor
anastrozole
her2/neu-positive breast cancer
letrozole
mammogram

Summary

This is a single-center Ib / II study of triple targeted drug combination (endocrine therapy,novel HER2-targeted small molecule inhibitor pyrotinib and CDK4/6 inhibitor dalpiciclib(SHR6390) ) as a first or second line of therapy in patients with relapsed/metastatic hormone receptor positive and HER2-positive breast cancer.

Description

This is a single-center, single arm, open-label, run-in phase Ib / roll-over phase II study of endocrine therapy in combination with novel human epidermal growth factor receptor-2(HER2)-targeted tyrosine kinase Inhibitor pyrotinib and cyclin-dependent kinase 4/6(CDK4/6) Inhibitor dalpiciclib(SHR6390) in subjects with hormone receptor(HR)+/HER2+ relapsed or metastatic breast cancer. The study will enroll natural postmenopausal women, or women who have undergone bilateral oophorectomy.The phase Ib part of the study will determine safety and tolerability of the combination of endocrine therapy, pyrotinib and dalpiciclib to define that appropriate dose of dalpiciclib for phase II.Data from phase Ib showed the triplet of pyrotinib, dalpiciclib, andendocrine therapy had an acceptable safety profile and encouraging efficacy, potentially offering a chemotherapy-sparing treatment option for patients with HER2-positive/HR-positive MBC.Once the recommended regimen has been identified, subjects with the selected tumor type will be enrolled into expansion cohorts for the purpose of assessing efficacy and safety of the combination treatment.

Details
Condition Breast Cancer
Treatment Letrozole, fulvestrant, Pyrotinib, SHR6390, Dalpiciclib(SHR6390)
Clinical Study IdentifierNCT03772353
SponsorFudan University
Last Modified on25 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Subjects voluntarily joined the study, signed informed consent, and had good compliance
Postmenopausal or premenopausal perimenopausal female patients aged ≥ 18 years and ≤ 75 years old,Meet one of the following
Previous bilateral oophorectomy, or age ≥ 60 years; or Age <60, natural postmenopausal state (defined as regular months for at least 12 consecutive months After spontaneous cessation and no other pathological or physiological reasons),E2 and FSH in menopause Post-level; or
HER2 positivity is defined by standard of 3+ staining by immunohistochemical staining (IHC) or positive for in situ hybridization (ISH)
Pre-menopausal or perimenopausal female patients can also be included, but must be willing to receive treatment with LHRH agonists
Patients with HR+/HER2+ recurrent or metastatic breast cancer confirmed by
histopathology
Local recurrence needs to be confirmed by the physician that is unresectable
Estrogen receptor(ER) or Progesterone receptor(PR) positive is defined as the percentage of cells positive for ER or PR expression ≥ 1%
Prior treatment
Previously received no more than 1 prior lines of systemic treatment with trastuzumab regimen for repetitive metastatic diabetes [including anti-HER2 ADC, subsequent meaning is the same]
At least one extracranial measurable lesion according to Response Evaluation Criteria
in Solid Tumors (RECIST) criteria version 1.1
The first-line treatment fails with the trastuzumab-containing regimen, or the trastuzumab-containing regimen recurs during the adjuvant treatment or relapses within 1 year after the adjuvant treatment ends, the follow-up treatment will be included as the second-line anti-HER2 treatment
The early stage includes trastuzumab-containing regimen treatment, or trastuzumab-containing regimen that relapses more than 1 year after the end of adjuvant treatment, and subsequent treatment is included as the first-line anti-HER2 treatment
Adequate function of major organs meets the following requirements (no blood components and cell growth factors have been used within 14 days before randomization)
Have not received anti-HER2 TKI treatment before or received but did not prove
that the treatment failed
Past endocrine therapy has not proven resistance to aromatase inhibitors (definition of resistance: recurrence during or within 1 year after treatment with adjuvant aromatase inhibitors, received aromatase inhibitors in the recurrence and metastasis stage and disease progression), follow-up Letrozole is selected for endocrine therapy. Past endocrine therapy has aromatase inhibitor resistance, and follow-up endocrine therapy is fulvestrant
Eastern Cooperative Oncology Group Performance Status of 0-1
Life expectancy ≥ 12 weeks
Neutrophils ≥ 1.5×10^9/L
Platelets ≥ 90×10^9/L
Hemoglobin ≥ 90g/L
Total bilirubin≤ 1.5 × the upper limit of normal (ULN)
ALT and AST ≤ 2.5 × ULN
BUN and Cr ≤ 1.5 × ULN
Left ventricular ejection fraction (LVEF) ≥ 50%
QTcF(Fridericia correction) ≤ 470 ms
International normalized ratio(INR)≤1.5 × ULN,activated partial thromboplastin time(APTT) ≤ 1.5 × ULN

Exclusion Criteria

Previously received any CDK4/6 inhibitor treatment
There are ascites, pleural effusion, pericardial effusion with clinical symptoms at baseline, those who need drainage, or those who have undergone drainage of serous effusion within 4 weeks before the first dose
Inability to swallow, intestinal obstruction or other factors affecting the administration and absorption of the drug
Received systemic therapy such as chemotherapy, molecular targeted therapy or other clinical trial drugs within 4 weeks before enrollment; received endocrine therapy within 2 weeks before enrollment
Meningeal metastasis or active brain parenchymal metastasis. Patients with clinically stable brain parenchymal metastases can be included, including asymptomatic brain metastases that have not received local treatment; or patients who have previously received central nervous system metastasis therapy (radiotherapy or surgery), if imaging confirms that stability has been maintained for at least 4 weeks , and have stopped symptomatic treatment (including hormones and mannitol, etc.) for more than 2 weeks
Patients with other malignant tumors within 5 years or at the same time( except for cured skin basal cell carcinoma and cervical carcinoma in situ)
Have undergone major surgical procedures or significant trauma within 4 weeks prior to randomization, or are expected to undergo major surgery
Pregnant women, lactating female, or women of childbearing age who are unwilling to take effective contraceptive measures
Have a history of allergies to the drug components of this regimen
Patients with active HBV and HCV infection; stable hepatitis B after drug treatment (HBV virus copy number is higher than the upper limit of reference value) and cured hepatitis C patients (HCV virus copy number exceeds the lower limit of detection method)
History of immunodeficiency, including HIV positive, or other acquired or congenital immunodeficiency disease, history of organ transplantation
Female patients who are pregnancy, lactation or women who are of childbearing potential tested positive in baseline pregnancy test
Childbearing female who refuse to accept any contraception practice
Determined by the physician, any serious coexisting disease might be harmful to the patient's safety or avoid the patients from accomplishing the treatment(e.g serious hypertension, diabetes, thyroid dysfunction,active infection etc.)
History of neurological or psychiatric disorders, including epilepsy or dementia
History of cardiac dysfunction, include(1)angina (2)clinical significant arrythmia or require drug intervention (3)myocardial infarction (4)heart failure (5) other cardiac dysfunction (judged by the physician); any cardiac or nephric abnormal ≥ grade 2 found in screening
Severe infections within 4 weeks prior to first dose (eg, intravenous infusion of antibiotics, antifungal or antiviral drugs according to clinical protocols), or unexplained fever (T > 38.3 °C ) during screening or prior to first administration
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