Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study (SEAL-IT)

  • days left to enroll
  • participants needed
  • sponsor
    The Cleveland Clinic
Updated on 21 February 2022


The purpose of the study is to evaluate how well tolerated and effective an angiotensin receptor-neprilysin inhibitor (sacubitril-valsartan) is in patients with contemporary durable continuous flow left ventricular assist device (CF-LVAD) implantation compared to usual care oral vasodilator therapy.


The aim of this pilot study is to prospectively determine the short-term (at 3 months) and long-term (at 6 and 12 months) safety and efficacy of an angiotensin receptor-neprilysin inhibitor (sacubitril-valsartan) in patients with contemporary durable continuous flow left ventricular assist device (CF-LVAD) implantation compared to standard-of-care (usual care) oral vasodilator therapy.

Condition Stage D Heart Failure
Treatment Sacubitril-Valsartan, Usual care (standard-of-care) arm
Clinical Study IdentifierNCT04191681
SponsorThe Cleveland Clinic
Last Modified on21 February 2022


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