Prognostic Significance of Fatty Liver Disease in Bariatric Patients (PROMETHEUS)

  • End date
    Apr 1, 2038
  • participants needed
  • sponsor
    Hospital of South West Jutland
Updated on 2 October 2023
liver disease
fatty liver
bariatric surgery


Prospective non-randomized intervention case control study on patients with a BMI > 35. The intervention group/cases (n=600) is comprised of bariatric patients who undergo bariatric surgery and the control group (n=600) of age, weight and comorbidity matched patients who choose not to undergo bariatric surgery. The overall aim is to examine prevalence of the spectrum of fatty liver disease (NAFLD) in these patients and the prognostic significance of NAFLD.

Condition Non-Alcoholic Fatty Liver Disease, Metabolic Encephalopathy, Obesity, Morbid, Non-alcoholic Steatohepatitis
Treatment Bariatric Surgery
Clinical Study IdentifierNCT03535142
SponsorHospital of South West Jutland
Last Modified on2 October 2023


Yes No Not Sure

Inclusion Criteria

Age > 18 years
BMI >35 kg/m2 and referred for bariatric surgery at Hospital of South West Jutland, Denmark
Able to give written informed consent
Inclusion criteria control group
Age > 18 years
BMI >35 kg/m2 with no wish to undergo bariatric surgery
Able to give written informed consent

Exclusion Criteria

Active viral hepatitis
Not willing or able to consent
Contraindications to liver biopsy
Clear my responses

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