Integrative Medicine for Pain in Patients With Advanced Cancer Trial (IMPACT)

  • End date
    Sep 7, 2023
  • participants needed
  • sponsor
    Memorial Sloan Kettering Cancer Center
Updated on 20 February 2022
pain relief
breast cancer
traditional chinese medicine
electrical stimulation
advanced cancer
ampullary cancer
neck cancer
fallopian tube cancers
unresectable liver cancer
gastrointestinal cancer


The purpose of this study is to compare the long-term effectiveness of acupuncture versus massage in people living with advanced cancer. The study will test how the two approaches compare in helping people with pain and its related symptoms and improving quality of life.

Condition Cancer Pain
Treatment Acupuncture, Massage
Clinical Study IdentifierNCT04095234
SponsorMemorial Sloan Kettering Cancer Center
Last Modified on20 February 2022


Yes No Not Sure

Inclusion Criteria

Age 18 years or older
Having a diagnosis of the following: stage III or IV lung cancer; any stage pancreatic cancer; unresectable cholangiocarcinoma; unresectable liver cancer; unresectable ampullary or peri-ampullary cancer or other stage IV gastrointestinal cancer; stage III or IV ovarian or fallopian tube cancers or other stage IV gynecologic cancer; stage IV breast cancer; stage III testicular cancer; stage IV genitourinary cancer; stage III or IV sarcoma; stage IV melanoma; stage III or IV head/neck cancer; stage IV endocrine cancer; or hematological malignancies (lymphoma, myeloma, and leukemia)
Be ambulatory (Karnofsky functional score of 60)
Having musculoskeletal pain, defined as regional (joints, extremities, back, neck) or more generalized (fibromyalgia or chronic widespread pain); Patients with a neuropathic component to their pain that involves the extremities or back will be eligible
Having musculoskeletal pain for at least 1 month
Having had pain for at least 15 days in the preceding 30 days
Having a pain rating of 4 or greater in worst pain on a 0-10 numerical rating scale in the preceding week
Having an expected prognosis of greater than six months as judged by the treating oncologist or study physician

Exclusion Criteria

Having a platelet count <15,000
Cognitive impairment precluding response to study assessments
Unwilling to accept random assignment
Unwilling to commit to the 26-week study time period
Have non-musculoskeletal pain syndromes (headache, facial pain, chest pain, visceral abdominal pain) if these are the sole source of pain but can be present as co-morbid conditions as long as a patient has a primary musculoskeletal pain condition defined as above
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What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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