Theta Burst Transcranial Magnetic Stimulation of Fronto-parietal Networks: Modulation by Mental State

  • STATUS
    Recruiting
  • End date
    May 31, 2022
  • participants needed
    48
  • sponsor
    University of Michigan
Updated on 20 June 2021

Summary

The purpose of this study is to improve understanding of the way transcranial magnetic stimulation (TMS), a form of non-invasive brain stimulation, affects the brain. The study hypothesis that when theta burst stimulation (TBS) is applied during a controlled mental state, network changes will be facilitated, compared to stimulation when mental state is uncontrolled. This study will focus on the dorsolateral prefrontal cortex (dlPFC) and the associated frontoparietal network (FPN), which subserves cognitive control - the ability to flexibly adapt and regulate behavior, an ability known to be impaired in neuropsychiatric conditions such as depression and dementia.

Healthy volunteers that qualify for this study will have psychological assessments and cognitive measures, as well as functional Magnetic Resonance Imaging (fMRI) scans, completed after administration of TMS. Participants will be asked to come in for a total of five visits that include; a screening and assessment visit; a baseline functional magnetic resonance imaging (fMRI) scan, followed by TMS session; Visits 3, 4, and 5 will be the experimental TMS session, followed by fMRI scan.

Description

Please note the collaborator (NIMH) is requesting that an NCT number be obtained prior to receiving the award.

Details
Condition healthy
Treatment TMS, n-back working memory task
Clinical Study IdentifierNCT04010461
SponsorUniversity of Michigan
Last Modified on20 June 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Women of child bearing age can not be pregnant or trying to become pregnant
Ability to tolerate small, enclosed spaces without anxiety
Size compatible with scanner gantry, e. g. men over 6 feet tall that weigh more than 250 lbs, men under 6 feet tall that weigh over 220 lbs, women over 5'11" tall that weigh more than 220 lbs, or women under 5'10" tall that weigh more than 200 lbs. Subjects of these weights or greater typically have difficult fitting into the fMRI scanner properly
Ability and willingness to give informed consent to participate
Alcohol or drug dependence (if in remission for greater than 5 years)

Exclusion Criteria

History of past or current mental illness (except simple phobias)
History of closed head injury, for example, loss of consciousness > approximately 5 minutes, hospitalization, neurological sequela
Metals, implants or metallic substances within or on the body that might cause adverse effects to the subject in a strong magnetic field, or interfere with image acquisition (for example; aneurysm clips, retained particles or metal workers with exposures, neurostimulators, foil-backed transdermal patches, carotid or cerebral stents, cerebral spinal fluid (CSF) shunts; magnetic dental implants, ferromagnetic ocular implants, pacemakers, and automatic implantable defibrillators)
Prescription or non-prescription, with psychotropic effects (birth control medications allowed)
First-degree family members with a history of epilepsy
History of serious neurological illness or current medical condition that could compromise brain function, such as liver failure
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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