The Effectiveness of Patient-tailored Treatment in Patients With (Sub)Acute Neck Pain

  • End date
    Oct 2, 2025
  • participants needed
  • sponsor
    University Ghent
Updated on 20 February 2022
manual therapy
arm pain
neck exercises


The purpose of this study is to assess the safety, tolerability, and efficacy of BMS-986158 alone and in combination with either Ruxolitinib or Fedratinib in participants with Dynamic International Prognostic Scoring System (DIPSS)-intermediate or high risk blood cancer. Part 1 consists of BMS-986158 in combination with either Ruxolitinib or Fedratinib and Part 2 consists of BMS-986158 in combination with either Ruxolitinib or Fedratinib and BMS-986158 alone.

Condition Neck Pain, Acute Pain, Rehabilitation, Physical Therapy Modalities
Treatment Education, patient-tailored therapy, Non-patient tailored therapy: generalized exercise program
Clinical Study IdentifierNCT04182035
SponsorUniversity Ghent
Last Modified on20 February 2022


Yes No Not Sure

Inclusion Criteria

Non-specific neck pain, pain located in the cervico-thoracic and posterior shoulder region; without dominant arm pain
NDI scores score 10 % (more than no disability) and 68 % (less than complete disability)
(Sub)acute complaints: <3 months
Recurrent complaints but no neck pain episode the previous 3 months
Mean pain intensity scores: NRS > 3/10

Exclusion Criteria

Structural pathology, confirmed by imaging (disk herniation, nerve root compression, radiculopathy, severe rheumatoid diseases, fractures, traumatic alterations) Shoulder pathology, vestibular pathology
Risk stratification: Startback tool for neck pain: high risk group
BMI > 30 kg/m
Other cardiovascular/metabolic/systemic/ neurological diseases, fibromyalgia or chronic fatigue syndrome
Psychiatric illnesses, history of depression, serious catastrophizing thoughts and/or low treatment expectations.[52]
Chronic complaints (>3 months) or traumatic onset of the complaints
Probable or definite neuropathic pain (according to the classification of Finnerup et al.)
History of surgery in the head/neck or shoulder region
Hypermobile patients
Pregnancy or given birth in the preceding year
History of recurrent/chronic low back pain
Primary headache
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