BMT-06: Study of Intensity Modulated Total Marrow Irradiation (IM-TMI)

  • STATUS
    Recruiting
  • End date
    Nov 4, 2024
  • participants needed
    27
  • sponsor
    University of Illinois at Chicago
Updated on 4 June 2021
remission
graft versus host disease
total body irradiation
fludarabine
tacrolimus
mycophenolate mofetil
cyclophosphamide
hla-a
myelodysplastic syndromes
acute leukemia
myeloproliferative disorder
flow cytometry
ejection fraction
leukemia
gilbert's syndrome
transplant conditioning
cytopenia
adult t-cell leukemia/lymphoma
hemolysis
chromosome abnormality

Summary

Pre-transplant conditioning will include targeted total marrow irradiation (TMI) at a dose of 6Gy. Graft-versus-host disease prophylaxis will include cyclophosphamide 50 mg/kg on Day +3 and 4 along with tacrolimus and mycophenolate mofetil

Description

This is a single arm phase II clinical trial. Patients will receive a standard conditioning regimen with fludarabine, cyclophosphamide and total body irradiation (Flu/Cy/TBI) prior to haploidentical hematopoietic stem cell transplant (HSCT). In addition the pre-transplant conditioning will include targeted total marrow irradiation (TMI) at a dose of 6Gy. Graft-versus-host disease prophylaxis will include cyclophosphamide 50 mg/kg on Day +3 and 4 along with tacrolimus and mycophenolate mofetil.

Details
Condition miller-dieker syndrome, MYELODYSPLASTIC SYNDROME, Myelodysplastic Syndromes (MDS), Acute Leukemia, MDS, myelodysplastic syndromes, myelodysplastic syndrome (mds), acute leukemias
Treatment Arm 1, Arm1
Clinical Study IdentifierNCT04187105
SponsorUniversity of Illinois at Chicago
Last Modified on4 June 2021

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