Last updated on June 2020

A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations


Brief description of study

The purpose of this study is to evaluate the efficacy of erdafitinib in terms of overall response rate (ORR) in participants with advanced solid tumors with fibroblast growth factor receptor (FGFR) mutations and gene fusions.

Detailed Study Description

Erdafitinib is a selective and potent pan FGFR 1-4 inhibitor with demonstrated clinical activity in participants with metastatic urothelial cancer and cholangiocarcinoma identified to have alterations in the FGFR pathway. This study targets the underlying altered biology of FGFR-driven tumors irrespective of solid tumor histology subtype. The study consists of screening phase, treatment phase and the post treatment follow-up phase (from the end of treatment visit until the participants has died, withdraws consent, is lost to follow-up, or the end of study, whichever comes first). End of study is defined as 4 years from enrollment of last participant into study or last follow-up visit of last patient, whichever occurs first.

Clinical Study Identifier: NCT04083976

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Highlands Oncology Group

Fayetteville, AR United States
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Rocky Mountain Cancer Centers

Colorado Springs, CO United States
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Yale University

New Haven, CT United States
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Memorial Cancer Institute

Hollywood, FL United States
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Emory University

Atlanta, GA United States
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Maine Medical Center

Scarborough, ME United States
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Mount Sinai

New York, NY United States
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Thomas Jefferson University

Philadelphia, PA United States
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Tennessee Oncology, PLLC

Chattanooga, TN United States
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Tennessee Oncology

Nashville, TN United States
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MD Anderson

Houston, TX United States
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Aurora Research Institute

Wauwatosa, WI United States
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Hospital Aleman

Buenos Aires, Argentina
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CEMIC Saavedra

Ciudad Autonoma Buenos Aires, Argentina
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Instituto Fleni

Ciudad Autonoma de Buenos Aires, Argentina
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Instituto de Investigaciones Metab licas

Ciudad Autónoma de Buenos Aires, Argentina
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Hospital Italiano de La Plata

La Plata Lpl Lpl, Argentina
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ARS M dica

San Salvador de Jujuy, Argentina
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UZA

Edegem, Belgium
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UZ Gent

Gent, Belgium
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Oncocl nicas

Rio de Janeiro, Brazil
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GRAACC

São Paulo, Brazil
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Centre Jean Perrin

Clermont Ferrand, France
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Charit

Berlin, Germany
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Asan Medical Center (AMC)

Seoul, Korea, Republic of
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Asan Medical Center

Seoul, Korea, Republic of
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Samsung Medical Center

Seoul, Korea, Republic of
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Inst. Cat. Doncologia-H Duran I Reynals

Hospitalet de Llobregat, Barcelona, Spain
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E-Da Cancer Hospital

Kaohsiung City, Taiwan
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Freeman Hospital

Newcastle, United Kingdom
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Derriford Hospital

Plymouth, United Kingdom
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Instituto de Investigaciones Metab licas

Ciudad Autónoma de Buenos Aires, Argentina
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GRAACC

São Paulo, Brazil
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Severance Hospital

Seoul, Korea, Republic of
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Henry Ford Hospital

Detroit, MI United States
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Instituto de Investigaciones Metab licas

Ciudad Autónoma de Buenos Aires, Argentina
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GRAACC

São Paulo, Brazil
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Instituto de Investigaciones Metab licas

Ciudad Autónoma de Buenos Aires, Argentina
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GRAACC

São Paulo, Brazil
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CEMIC Saavedra

Ciudad Autonoma de Buenos Aires, Argentina
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Instituto de Investigaciones Metab licas

Ciudad Autónoma de Buenos Aires, Argentina
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ARS M dica

San Salvador De Jujuy, Argentina
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GRAACC

São Paulo, Brazil
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Instituto de Investigaciones Metab licas

Ciudad Autónoma de Buenos Aires, Argentina
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ARS M dica

San Salvador De Jujuy, Argentina
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Oncocl nicas

Rio de Janeiro, Brazil
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Charit

Berlin, Germany
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Oncology Hematology Care

Cincinnati, OH United States
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AZ Klina

Brasschaat, Belgium
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Jolimont

Haine-Saint-Paul, La Louviere, Belgium
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Recruitment Status: Open


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