Correlation Between TILs and Blood Cell Counts in Triple Negative Breast Cancer Patients (PERCEPTION)

  • STATUS
    Recruiting
  • End date
    Oct 27, 2027
  • participants needed
    90
  • sponsor
    Centre Jean Perrin
Updated on 27 June 2022
cancer
breast cancer
neutrophil count
triple negative breast cancer
Accepts healthy volunteers

Summary

The PERCEPTION study aims to assess the correlation between blood cell counts (Leucocytes, Neutrophils, Lymphocytes, Platelets, NLR (Neutrophil-to-Lymphocyte Ratio) and PLR (Platelet-to-Lymphocyte Ratio)) and Tumor Infiltrating Lymphocytes (TILs), at baseline and after surgery, for patients diagnosed with triple negative breast cancer. It also aims to assess these circulating elements and circulating tumor DNA as predictive factor of metastatic recurrence in triple negative breast cancer.

Description

Triple negative breast cancer (TNBC) is the most aggressive type of breast cancer. Because of the limited therapeutical strategies, early TNBC relapses are quite common during the five years following treatment.

It has been shown that the presence of tumor infiltrating lymphocytes (TILs) at baseline is related to good pathological response to neoadjuvant chemotherapy. In addition, the presence of a high quantity of TILs in the residual tumor after neoadjuvant chemotherapy is related to better survival rates.

Blood circulating elements, such as peripheral blood cells or circulating tumor DNA, could be of interest in predicting response to treatment and in the prediction of metastatic recurrences in different types of cancer, including breast cancer.

However, the correlation of these markers in triple negative breast cancer has not yet been thoroughly studied.

The PERCEPTION study aims to assess the correlation between blood cell counts (Leucocytes, Neutrophils, Lymphocytes, Platelets, NLR (Neutrophil-to-Lymphocyte Ratio) and PLR (Platelet-to-Lymphocyte Ratio)) and Tumor Infiltrating Lymphocytes (TILs), at baseline and after surgery, for patients diagnosed with triple negative breast cancer. It also aims to assess these circulating elements and circulating tumor DNA as predictive factor of metastatic recurrence in triple negative breast cancer.

Details
Condition Triple Negative Breast Cancer
Treatment Blood sample
Clinical Study IdentifierNCT04068623
SponsorCentre Jean Perrin
Last Modified on27 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Female
Age > 18 years
Diagnosed with primitive, non-metastatic, histologically proved, triple negative breast cancer
Patient treated with chemotherapy, surgery and radiation therapy
Patient able to understand the French language
Patient affiliated to social security
Obtaining signed written consent

Exclusion Criteria

Male
Unavailable tumoral samples before inclusion
Unavailable blood test results at baseline, before inclusion
Clear my responses

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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