Development of Clinical and Biological Database in Colorectal Cancer

  • STATUS
    Recruiting
  • End date
    Apr 26, 2023
  • participants needed
    100
  • sponsor
    Institut du Cancer de Montpellier - Val d'Aurelle
Updated on 26 January 2021
cancer
metastatic colorectal cancer
adenocarcinoma

Summary

Creation of circulating cancer cell-lines and caracterisation of these cell-lines which will be collected before any treatment in patients with metastatic colon adenocarcinoma

Description

In the light of literature data, it becomes crucial to develop models for studying the functionality of CTCs. In this context, xenograft models in nude mice have recently been described9,10. Establishing cell lines to allow CTC amplification to have enough material to work is an attractive approach. Some recent studies have demonstrated the feasibility of establishing such tools in breast or prostate cancer, 11, 12 but no studies have been done for colorectal cancer. Thus on the basis of the hypothesis that circulating tumor cells could be, or at least contain, cancerous stem cells, we propose to isolate them under conditions that promote their survival in order to characterize them in the particular context of colorectal cancer.

If CTCs consist at least in part of CSCs, they should survive in an environment favorable to the culture of these cells. It is for this reason that purified CTCs will be seeded in plaques that prevent cell adhesion and in a serum-free medium but including growth factors (M12) under hypoxia conditions to approximate their original context. The ability of these cells to form spheres will be observed under these conditions.

In this context, the team of the Institute of Functional Genomics of Montpellier are the first, to have developed and characterized three lines of CTC from blood samples of patients with metastatic colon cancer (Grillet F. and al; submitted for publication). In addition to the characterization of these rare cells and the decryption of some of the mechanisms involved in tumor dissemination, this tool is very valuable for the clinic. Indeed, it could help the establishment of personalized medicine to test quickly (less than 3 weeks) on the CTC of the patient, the effectiveness of conventional treatments but also new drugs included in clinical protocols. For the basic research part, this line will help us to characterize these cells because the number is no longer a limiting factor, the main objective now being to obtain more lines from a blood sample from patients with different profiles by optimizing cell culture conditions.

Details
Condition Metastatic Colon Cancer
Treatment Blood sample
Clinical Study IdentifierNCT04186117
SponsorInstitut du Cancer de Montpellier - Val d'Aurelle
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have Metastatic Colon Cancer?
Do you have any of these conditions: Do you have Metastatic Colon Cancer??
Do you have any of these conditions: Do you have Metastatic Colon Cancer??
Do you have any of these conditions: Do you have Metastatic Colon Cancer??
Male or female 18 years
Histological evidence of metastatic colorectal cancer
Nave patients receiving chemotherapy at the metastatic stage or who have received adjuvant chemotherapy for more than 6 months
Obtain signed informed consent prior to any specific preselection procedure

Exclusion Criteria

History of Chemotherapy Treatment and / or Targeted Therapy for Metastatic Colorectal Cancer
Breastfeeding or pregnant woman
Patient whose regular follow-up is impossible for psychological, family, social or geographical reasons
Any severe or unstable medical, psychiatric or other condition that may interfere with the patient's safety, consent or compliance with the study protocol
Patient not benefiting from a social security scheme
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