Tracking Information Flow in the Brain (BRAINDYN)

  • STATUS
    Recruiting
  • End date
    Apr 25, 2025
  • participants needed
    160
  • sponsor
    Hospices Civils de Lyon
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Updated on 24 May 2022
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Accepts healthy volunteers

Summary

The brain is composed of a set of areas specialized in specific computations whose outputs need to be transferred to other specialized areas for cognition to emerge. To account for context-dependent behaviors, the information must be flexibly routed through the fixed anatomy of the brain. The aim of this project is to test a general framework for this flexible communication between brain areas based on nested oscillations. The general idea is that internally-driven slow oscillations (<20Hertz) either set-up or prevent the communication between brain areas. Stimulus-driven gamma oscillations (>30Hertz), nested in the slow oscillations, can then be directed to task-relevant areas of the network. This multimodal, multi-scale approach uses magnetoencephalography using a 3-Dimensional (3D) printed individual head-cast system and transcranial stimulation in experiments manipulating visual processing, attention and memory to test core predictions of this framework. The theoretical approach and the methodological development used in this basic science study will provide the basis for future fundamental and clinical research.

Details
Condition Healthy Volunteer
Treatment Visual attention/perception tasks in healthy participants
Clinical Study IdentifierNCT04175119
SponsorHospices Civils de Lyon
Last Modified on24 May 2022

Eligibility

 Yes No Not Sure

Inclusion Criteria

-36 years old
Right handed
Registered with the French healthcare system
Motivated to participate in the study
Normal or corrected vision
Adequate knowledge of French to be able to follow directions and give informed consent
Capacity to listen and follow study instructions
Use of contraception (in sexually active women)
BMI between 18.5 and 30
Informed consent for participation in the study

Exclusion Criteria

For All Experiments
Persons with
Sleep disorders, neurological or psychiatric illnesses or a history of such problems that could impact quality/variability of data or cooperation and retention of the subject in the study
Migraines or light-sensitive epilepsy
Regular use of medications that impact the central nervous system
Regular use of medications, such as opioids and antidepressants, including Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants
Severe hearing loss
Skin conditions or allergies
Chronic pain, or any other medical conditions conducive to pain sensitivity
A history of stroke or recent trauma to the head
A pacemaker, insulin or other pump, neurostimulator, cochlear implants or other hearing aid, metal stents, prosthesis, or implants, intracerebral clips, implantable defibrillator, cerebral shunt or ventricular catheter, other foreign metal objects in the upper part of the body
Persons unable to adhere to abstinence from the use of drugs or alcohol the day or
Women who are pregnant, breastfeeding, or have given birth in the last 6 months
evening before experimental sessions
For experiments using magnetoencephalography
Persons with
claustrophobia
any dental apparatus containing metal including or root canals
any foreign metallic object anywhere in the body
bolts, screws
orthopedic devices or implants
glasses (given the participant cannot use contact lenses)
a head size incompatible with the use of a personalized 3D head-cast or a magnetoencephalograph
Persons having had any surgery prior to the study which puts them at risk for metal
objects left in the body
Anxious, non-cooperative, or agitated persons
For experiments using Magnetic Resonance Imaging (MRI) or Functional Magnetic Resonance
Claustrophobia
Imaging (fMRI) techniques
For experiments using transcranial stimulation
Persons having had any surgery prior to the study which puts them at risk for metal
objects left in the body
Persons with frequent syncope episodes (loss of consciousness) as a result of any
particular sensorial stimulations
Clear my responses
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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