Baclofen as a Perioperative Analgesic Adjuvant

  • STATUS
    Recruiting
  • End date
    Sep 14, 2022
  • participants needed
    86
  • sponsor
    University of Alabama at Birmingham
Updated on 19 February 2022
analgesics
opioid

Summary

The purpose of this study is to determine whether a single, oral dose of baclofen alters postoperative opioid requirements.

Description

Postoperative pain continues to be a significant clinical problem. Use of perioperative adjuvants has improved postoperative pain control. The GABA-B receptor agonist, baclofen, is an appropriate drug to trial as such an analgesic adjuvant. Therefore, the investigators will conduct a study designed to determine whether or not a single, oral dose of baclofen given to patients undergoing kidney stone surgery will reduce postoperative opioid requirements measured in the first 24 hours following surgery.

Details
Condition Pain
Treatment Placebo, Baclofen 10mg
Clinical Study IdentifierNCT03720717
SponsorUniversity of Alabama at Birmingham
Last Modified on19 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult patients (age >= 19 y.o.) scheduled for kidney stone-related surgery

Exclusion Criteria

History of allergy to baclofen
Any condition which might limit appropriate report and treatment of postoperative pain (e.g., non-English speaking; severe psychiatric disease)
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