MUltimodal Targeted Axillary Surgery (MUTAS)

  • participants needed
  • sponsor
    Parc de Salut Mar
Updated on 1 December 2022


The present trial will prospectively evaluate the accuracy of both a systematic predefined axillary ultrasound imaging together with tumor load quantification of suspicious and sentinel axillary lymph nodes to predict overall tumor load in the axilla.


Axillary node clearance (ANC) is a controversial intervention in the surgical treatment of breast cancer. Different studies have shown that in some patients with infiltrated axillary lymph nodes but low tumor burden, ANC can be safely omitted. However, indications for ANC persist in nowadays for patients with positive axillary lymph nodes and upfront surgery and patients with positive lymph nodes after neoadjuvant treatment. The present prospective study will evaluate the ability to establish an axillary tumor load with two steps. The first step will be a preoperative predefined systematic axillary ultrasound imaging workflow. The second step will be the tumor load evaluation of suspicious and sentinel axillary lymph nodes. We will also evaluate which patients have infiltrated nodes only beneath the second intercostobrachial nerve. The trial intends to identify patients for who a complete axillary node clearance could be spared.

Condition Node-positive Breast Cancer
Treatment Systematic axillary ultrasound imaging, Sentinel node, Sentinel node, Excision of suspicious lymph nodes, Two steps axillary node clearance
Clinical Study IdentifierNCT04039893
SponsorParc de Salut Mar
Last Modified on1 December 2022

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