Study of Olaparib (MK-7339) in Combination With Pembrolizumab (MK-3475) in the Treatment of Homologous Recombination Repair Mutation (HRRm) and/or Homologous Recombination Deficiency (HRD)-Positive Advanced Cancer (MK-7339-007/KEYLYNK-007)

  • STATUS
    Recruiting
  • End date
    Dec 11, 2023
  • participants needed
    300
  • sponsor
    Merck Sharp & Dohme Corp.
Updated on 25 November 2020
Investigator
Toll Free Number
Primary Contact
Zhytomyr Regional Oncology Center ( Site 1710) (0.0 mi away) Contact
+130 other location
cancer
measurable disease
pembrolizumab
advanced cancer
solid tumor
mk-3475
cancer of the ovary

Summary

The purpose of this study is to assess the efficacy and safety of treatment with olaparib (MK-7339) in combination with pembrolizumab (MK-3475) in adults with previously treated, advanced (metastatic and/or unresectable) Homologous Recombination Repair Mutation (HRRm) and/or Homologous Recombination Deficiency (HRD)-positive solid tumors.

Details
Treatment Pembrolizumab, olaparib
Clinical Study IdentifierNCT04123366
SponsorMerck Sharp & Dohme Corp.
Last Modified on25 November 2020

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Eligibility

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Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have Solid Tumors?
Do you have any of these conditions: Solid Tumour or Solid Neoplasm or Solid Tumors?
Do you have any of these conditions: Solid Tumour or Solid Neoplasm or Solid Tumors?
Do you have any of these conditions: Solid Tumors or Solid Tumour or Solid Neoplasm?
Do you have any of these conditions: Solid Neoplasm or Solid Tumors or Solid Tumour?
Has a histologically- or cytologically-confirmed advanced (metastatic and/or unresectable) solid tumor (except breast or ovarian cancers whose tumor has a germline or somatic BRCA mutation) that is not eligible for curative treatment and for which standard of care therapy has failed. Participants must have progressed on or be intolerant to standard of care therapies that are known to provide clinical benefit. There is no limit on the number of prior treatment regimens
Has either centrally-confirmed known or suspected deleterious mutations in 1 of the specified 15 genes involved in HRR or centrally-confirmed HRD based on the Lynparza HRR-HRD assay
Has measurable disease per RECIST 1.1 as assessed by the local site investigator/radiology and confirmed in real time by blinded independent central review (BICR). BICR must confirm the presence of radiologically measurable disease per RECIST 1.1 for the participant to be eligible for the study
Has a life expectancy of 3 months
Has an Eastern Cooperative Oncology Group (ECOG) performance status of either 0 or 1, as assessed within 3 days of study treatment initiation
Male participants must agree to use contraception during the treatment period and for 120 days (4 months) after last dose of study treatment and refrain from donating sperm during this period
Female participants must not be pregnant or breastfeeding, and 1 of the following conditions applies
Is not a woman of childbearing potential (WOCBP) OR
Is a WOCBP who agrees to use contraception during the treatment period and for 180 days (6 months) after the last dose of study treatment
Has adequate organ function

Exclusion Criteria

Has a known additional malignancy that is progressing or has required active treatment in the last 3 years. Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, ductal carcinoma in situ, or cervical carcinoma in situ that has undergone potentially curative therapy are not excluded
Has a history of non-infectious pneumonitis that required treatment with steroids or currently has pneumonitis
Has myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) or with features suggestive of MDS/AML
Has known central nervous system (CNS) metastases and/or carcinomatous meningitis
Has an active infection requiring systemic therapy
Has active tuberculosis (Bacillus tuberculosis [TB])
Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (dosing >10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of study treatment
Has an active autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs)
Has received colony-stimulating factors (e.g. granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor [GM-CSF] or recombinant erythropoietin) within 28 days prior to the first dose of study treatment
Has a known history of human immunodeficiency virus (HIV) infection
Has known active hepatitis B or hepatitis C
Is unable to swallow orally administered medication or has a gastrointestinal (GI) disorder affecting absorption (e.g. gastrectomy, partial bowel obstruction, malabsorption)
Has received prior therapy with an anti-programmed death-1 (anti-PD-1), anti-programmed death-ligand 1 (anti-PD-L1), or anti-programmed death-ligand 2 (anti-PD-L2) agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g. cytotoxic T-lymphocyte-associated protein 4 [CTLA-4], OX 40 [Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4)], CD137 [tumor necrosis factor receptor superfamily member 9 (TNFRSF9)])
Has received prior therapy with olaparib or with any other polyadenosine 5' diphosphoribose (poly[ADP ribose]) polymerization (PARP) inhibitor
Was refractory to prior platinum therapy (cisplatin, carboplatin, or oxaliplatin either as monotherapy or in combination) for advanced (metastatic and/or unresectable) solid tumor
Has received prior systemic anti-cancer therapy including investigational agents within 4 weeks prior to administration of study treatment
Must have recovered from all adverse events (AEs) due to previous therapies, excluding alopecia, to Grade 1 or Baseline
Has a known hypersensitivity to the study treatments and/or any of their excipients
Is currently receiving either strong inhibitors of cytochrome P450 (CYP)3A4 (e.g. itraconazole, telithromycin, clarithromycin, protease inhibitors boosted with ritonavir or cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir) or moderate inhibitors of CYP3A4 (e.g. ciprofloxacin, erythromycin, diltiazem, fluconazole, verapamil) that cannot be discontinued for the duration of the study. The required washout period prior to starting olaparib is 2 weeks
Is currently receiving either strong inducers of CYP3A4 (phenobarbital, enzalutamide, phenytoin, rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's Wort) or moderate inducers of CYP3A4 (e.g. bosentan, efavirenz, modafinil) that cannot be discontinued for the duration of the study. The required washout period prior to starting olaparib is 5 weeks for phenobarbital and 3 weeks for other agents
Has received previous allogenic bone-marrow transplant or double umbilical cord transplantation (dUCBT)
Has received a whole blood transfusion in the last 120 days prior to entry to the study
Has received prior radiotherapy within 2 weeks of start of study treatment
Is currently enrolled in and receiving study therapy, was enrolled in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks (28 days) of the first dose of study treatment
Has resting electrocardiogram (ECG) indicating uncontrolled, potentially reversible cardiac conditions, as judged by the investigator (e.g. unstable ischemia, uncontrolled symptomatic arrhythmia, congestive heart failure, corrected QT interval by Fredericia [QTcF] prolongation >500 msec, electrolyte disturbances), or participant has congenital long QT syndrome
Has either had major surgery within 2 weeks of starting study treatment or has not recovered from any effects of any major surgery
Has received a live vaccine within 30 days prior to the first dose of study treatment
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