Impact of Chemotherapy and Regenerative Markers of Liver Regeneration After Liver Resection for Liver Metastases

  • STATUS
    Recruiting
  • End date
    Apr 1, 2022
  • participants needed
    100
  • sponsor
    Vilnius University
Updated on 23 January 2021
cancer
metastasis
hepatectomy

Summary

Liver is special organ, which can regenerate. On that ability there are many treatment modalities, where liver resection is performed, especially in cancer patients with liver metastases. Liver regeneration provides an opportunity for these patients to undergo multiple treatment regimes and liver resections to achieve curability. There are many factors that impair liver regeneration. One of these factors is chemotherapy. Literature data on impact of chemotherapy to liver regeneration is ambiguous. Therefore we aim to research impact of chemotherapy to liver regeneration.

Description

Liver is the largest parenchymal organ responsible for over 500 different functions in human body, which are detoxification of various toxins, drugs, synthesis of proteins and enzymes, coagulation factors. Liver is special organ, which can regenerate. If 75% of liver is removed it can regenerate to its normal size. Liver volume is very important to liver function, if there is volume insufficiency it could lead to liver failure in addition to other factors that impair liver regeneration. On that regenerative ability there are many treatment modalities, when liver resection is performed, especially in cancer patients with liver metastases. Modern treatment modalities are based on combination of different treatments, surgical and chemotherapeutic. On the other hand, side effects of chemotherapy should not be discarded, which can increase patient morbidity and mortality. Thus, liver regeneration provides an opportunity for these patients to undergo multiple treatment regimes and liver resections to achieve curability. Literature data on impact of chemotherapy to liver regeneration is ambiguous. Therefore we aim to research impact of chemotherapy to liver regeneration.

Details
Condition Liver Regeneration, Liver Metastases, Liver Metastasis, Secondary Malignant Neoplasm of Liver, Hepatic Metastases
Treatment Liver Resection
Clinical Study IdentifierNCT04178759
SponsorVilnius University
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients with liver lesions, who are eligible for liver resection

Exclusion Criteria

Pregnant women
Liver resection is not performed
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