Last updated on December 2019

Vaginal Cuff Brachytherapy Fractionation Study

Brief description of study

The purpose of this study is to see the effects of two different standard of care treatments of endometrial cancer on sexual dysfunction. This study will compare two standard of care treatments: HDR (high dose radiation) vaginal brachytherapy 3 fractions of 7 Gy (Arm 1) to HDR vaginal brachytherapy 6 fractions of 4Gy (Arm 2) for early stage endometrial cancer.

Detailed Study Description

Patients are randomized to Arm 1: HDR vaginal brachytherapy 7 Gy in 3 fractions prescribed at 5mm. Radiation delivered 4-12 weeks after surgery OR Arm 2: HDR vaginal brachytherapy 4Gy in 6 fractions prescribed at the cylinder surface. Radiation delivered 4-12 weeks after surgery. Participants in both arms will receive standard vaginal dilator for use after treatment (to promote healing). 1 and 2 year follow up assessments are performed.

Clinical Study Identifier: NCT03785288

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University of Virginia

Charlottesville, VA United States
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