A Research Study in Chinese People With Allergy to House Dust Mites, Using an Environmental Exposure Chamber (QUEST)

  • days left to enroll
  • participants needed
  • sponsor
    ALK-Abelló A/S
Updated on 19 February 2022
environmental exposure


This trial evaluates the efficacy and safety of HDM SLIT-tablet in treatment of HDM AR. The efficacy is evaluated using an environmental exposure chamber (EEC). Subjects will be randomised to receive treatment with HDM SLIT-tablet and placebo 1:1.


This trial is a 24 weeks, randomised, parallel-group, double-blind, placebo-controlled phase III trial. Approximately 202 subjects will be randomised (1:1) to receive treatment with HDM SLIT-tablet or placebo. The trial will be conducted in China, with subjects recruited and treated in China. Two EEC assessments (baseline and end of treatment) will take place at a validated EEC facility in Austria.

The primary objective is to demonstrate the efficacy of the HDM SLIT-tablet (12 SQ-HDM) once daily compared to placebo in the treatment of HDM AR nasal symptom determined during the EEC session at week 24.

Condition Allergic Rhinoconjunctivitis
Treatment Placebo, Sublingual allergy immunological tablet
Clinical Study IdentifierNCT04176185
SponsorALK-Abelló A/S
Last Modified on19 February 2022


Yes No Not Sure

Inclusion Criteria

Male or female Chinese subjects aged 18 years
A clinical history of HDM AR/C with or without asthma
Positive SPT and IgE to Der p or Der f at screening
A TNSS of at least 6 of 12 within the first 2 hours of the screening EEC session prior to randomisation

Exclusion Criteria

Sensitised and regularly exposed perennial or seasonal allergens
Asthma requiring treatment with high-dose ICS
Reduced lung function
Has a nasal condition that could confound the efficacy or safety assessment
A relevant history of systemic allergic reaction
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