MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics

  • End date
    Dec 17, 2022
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 19 February 2022
alzheimer's disease
normal pressure hydrocephalus
Accepts healthy volunteers


The Researchers are trying to test a MR imaging method for detection of Cerebral Spinal Fluid (CSF) flow in the brain to help diagnosis and better understand diseases that affect brain function.


The purpose of this research is to figure out if MR imaging can detect movement of CSF (fluid around the brain) to help better diagnosis and understand the cause of diseases that affect brain function. We are doing this research study to find out if movement of CSF is different between healthy adults and those with a disease that affects brain function.

Condition Hydrocephalus, Alzheimer Disease
Treatment Urine pregnancy test, MRI screening form, MR brain
Clinical Study IdentifierNCT04099823
SponsorMayo Clinic
Last Modified on19 February 2022


Yes No Not Sure

Inclusion Criteria

A healthy control will be defined as an otherwise healthy person who does not have a medical condition that affects brain function or have problems with concentration, memory, balance, or coordination
Patients who have a suspected diagnosis of altered CSF dynamics including but not limited to normal pressure hydrocephalus will be referred to Dr. Cogswell by their care team to be included in the study. Conditions of altered CSF dynamics include obstructive and non-obstructive hydrocephalus and may be associated with headaches and/or decreased cognitive function
Similarly, patients with impaired cognitive function including but not limited to Alzheimer's disease will be referred to Dr. Cogswell by their care team to be included in the study

Exclusion Criteria

Subjects with non-MRI compatible devices
required sedation
women who may be pregnant will be excluded
The first 10 subjects with normal pressure hydrocephalus will not have previously been shunted
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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