Impact of Bariatric Surgery in Obese Patients With and Without Obstructive Sleep Apnea Syndrome (COLOSS)

  • STATUS
    Recruiting
  • End date
    May 31, 2026
  • participants needed
    400
  • sponsor
    Ramsay Générale de Santé
Updated on 19 February 2022
gastrectomy
apnea
bariatric surgery
sleeve gastrectomy

Summary

It has been shown to date that obesity is associated with increased mortality and that weight loss significantly improves cardiovascular risk factors. Among patients receiving bariatric surgery, 30-90% have moderate to severe obstructive sleep apnea (OSA) syndrome. Given the strong associations between OSA and cardiometabolic comorbidities, this project is based on the hypothesis of a lower improvement of cardiovascular risk factors and a higher number of post-surgical complications in OSAS patients.

Description

It has been shown to date that obesity is associated with increased mortality and that weight loss significantly improves cardiovascular risk factors.

Bariatric surgery is now the most effective intervention for the long-term treatment of obesity and its complications. Among patients receiving bariatric surgery, 30-90% have moderate to severe obstructive sleep apnea (OSA) syndrome. The progressive loss of weight contributes to the regression of the symptoms related to OSA. Observational studies have shown that bariatric surgery can rapidly improve glycemic control and cardiovascular risk factors with a significantly higher remission rate of hypertension and dyslipidemias than in the non-surgical group. Given the strong associations between OSA and cardiometabolic comorbidities, this project is based on the hypothesis of a lower improvement of cardiovascular risk factors and a higher number of post-surgical complications in OSAS patients.

Details
Condition Obesity, Bariatric Surgery Candidate, Apnea, Obstructive
Treatment Bariatric Surgery
Clinical Study IdentifierNCT04179188
SponsorRamsay Générale de Santé
Last Modified on19 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient, male or female, aged over 18
Patient in preparation for bariatric surgery (ring, Sleeve gastrectomy or Bypass) in the center CELIOBE
Patient affiliated with social security or beneficiary of such a scheme
Patient having signed the free and informed consent

Exclusion Criteria

Patient who has already had bariatric surgery (ring, sleeve gastrectomy or bypass)
Patient already receiving CPAP treatment for sleep apnea syndrome
Patients with pathology indicating the use of CPAP in self-guided mode (heart failure with altered ejection fraction) for patients diagnosed with OSAS
Patient likely, in the opinion of the investigator, not to be cooperative or respectful of the obligations inherent to participation in the study
Patient suffering from mental pathology does not make possible the collection of a consent
Protected patient: major under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision
Pregnant, lactating or parturient woman
Patient hospitalized without consent
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