Last updated on December 2019

NOrth American Study for the Treatment of Recurrent epIstaxis With DoxycycLine: The NOSTRIL Trial

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Epistaxis
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Diagnosis of definite HHT by the Curacao criteria or genetic diagnosis of HHT
  • Epistaxis severity during observation month at least moderate by Epistaxis Severity Score (ESS) evaluation
  • For female participants, a negative pregnancy test at Day -1 and agree to use birth control during treatment and for 28 days following cessation of Doxycycline

Exclusion Criteria:

  • Use of medication(s) contraindicated with doxycycline use within 14 days prior to the study (including barbiturates, tegretol, dilantin, warfarin, isotretinoin)

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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