The Causal Relation of Nasal Nitric Oxide Levels to the Severity of Chronic Rhinosinusitis and Its Inflammatory Phenotype

  • End date
    Apr 24, 2022
  • participants needed
  • sponsor
    Tampere University Hospital
Updated on 24 January 2021
ct scan


Nitric oxide (NO) reflects changes in inflammatory state of the airways. In pulmonology fractional exhaled nitric oxide concentration (FeNO) has been linked to eosinophilic asthma and is used to guide overall disease control. The measurement of nasal nitric oxide (nNO) may reflect the disease burden and inflammatory phenotype of the paranasal sinuses.

The aim of our study is to evaluate the relation of chronic rhino sinusitis (CRS) severity and inflammatory status to nNO, maxillary sinus NO, nitrite, nitrate and cone beam computed tomography (CBCT).

Three groups (22 patients in each) of referred patients and and 22 healthy volunteers are recruited. Patients are grouped according to the CBCT score and viewed three times in 4-6 weeks intervals.

Condition Chronic Sinusitis, Chronic Rhinosinusitis
Treatment Fluticasone propionate
Clinical Study IdentifierNCT04171167
SponsorTampere University Hospital
Last Modified on24 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 70 yrs?
Gender: Male or Female
Do you have Chronic Rhinosinusitis?
Do you have any of these conditions: Chronic Rhinosinusitis or Chronic Sinusitis?
Patients willing to participate in the study
Patients who are referred to ENT clinic due to chronic rhinosinusitis (EPOS criteria) or repeatedly diagnosed and treated acute rhinosinusitis

Exclusion Criteria

Endoscopic sinus surgery operation previously
Septal deviation that would need an operation to correct the air flow
Other severe disease that could pose a risk for the patient during the measurements based on the judgement of the treating physician
Pregnancy or breastfeeding
Allergy to used medications
Inability to co-operate or to tolerate manipulation of the nose
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