Effect of Curcumin on Systemic Lupus Erythematosus

  • End date
    May 1, 2022
  • participants needed
  • sponsor
    Loma Linda University
Updated on 21 May 2021
treatment regimen


The purpose of this investigator initiated study is to determine the efficacy of curcumin on disease activity of subjects with systemic lupus erythematous. Curcumin has been found to have anti-inflammatory effects and has been found to improve disease activity in lupus patients. In addition, subjects with rheumatoid arthritis as well as osteoarthritis have also found benefit for their disease activity.

Condition Autoimmune Disease, Connective Tissue Diseases, Dermatomyositis (Connective Tissue Disease), Systemic Lupus Erythematosus, Autoimmune disease, CONNECTIVE TISSUE DISEASE, SYSTEMIC LUPUS ERYTHEMATOSUS
Treatment Curcumin supplement
Clinical Study IdentifierNCT03953261
SponsorLoma Linda University
Last Modified on21 May 2021


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Inclusion Criteria

Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Male or female, aged 18 or older
Diagnosed with Systemic Lupus Erythematous according to the 2012 Systemic Lupus International Collaborating Clinics Classification Criteria
SLEDAI score of 6 or higher
Ability to take oral medication and be willing to adhere to the study drug regimen

Exclusion Criteria

Inability to provide written consent for study participation
Use of curcumin supplements within 30 days of enrollment of study
Liver function disorders (AST/ALT > 2.5x upper limit of normal)
Pregnancy or lactation
Known allergic reactions to turmeric
Subjects who are admitted for recent hospitalization within past 60 days
Treatment with another investigational drug or other intervention within past 60 days
Subjects with end stage renal disease on dialysis
Subjects who lack the ability to provide consent
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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