Emotion Study/Substudy: Flexible Brain Study

  • STATUS
    Recruiting
  • End date
    Dec 30, 2022
  • participants needed
    226
  • sponsor
    University of Florida
Updated on 30 June 2022
depression
cognitive impairment
dementia
alzheimer's disease
parkinson's disease
tics
mild cognitive impairment
Accepts healthy volunteers

Summary

The proposed research applies the highly innovative technology of real-time functional Magnetic Resonance Imaging (rtfMRI) to examine plasticity of brain-regulatory mechanisms related to cognitive and affective processing and to determine benefits for cognition and affect in young and older adults and in Parkinson Disease (PD) patients.

Description

There is increasing evidence that age-related alterations in brain function associated with affective processing and attention contribute to these motivational and emotional changes with age.

Based on these theoretical considerations as well as the previous study's data, the proposed research will apply well-tested emotion processing and attention paradigms to address the pivotal question of whether brain activity can be modulated in healthy aging and PD (in the substudy) via contingent rt-fMRI neurofeedback and whether this neuroregulatory modulation increases emotion processing and cognitive performance.

Details
Condition Aging, Emotions, Parkinson Disease
Treatment Anterior cingulate cortex activation, Primary auditory cortex activation
Clinical Study IdentifierNCT03872414
SponsorUniversity of Florida
Last Modified on30 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Young adults
aged 18-35 years of age
native English speaker
at least 8th grade education
eligible for MRI as determined by the MRI Eligibility Interview (including not being pregnant)
scores within normal limits on a cognitive screener (MoCA)
no indication of serious psychiatric disturbance including major depression (based on Mental Health Screener)
willing and able to give informed consent
Inclusion Criteria: Older adults
age 55-100 years of age
native English speaker
at least 8th grade education
eligible for MRI as determined by the MRI Eligibility Interview
willing and able to give informed consent
Inclusion Criteria: Parkinson patients
must meet criteria for diagnosis of idiopathic Parkinson disease according the UK Brain Bank by a movement trained neurologist
age 55-100 years of age
native English speaker
at least 8th grade education
generally physically and neurologically healthy other than Parkinson disease
eligible for MRI as determined by the MRI Eligibility Interview
Inclusion Criteria: Individuals with SCD and a family history of dementia or Alzheimer's
no indication of dementia based on cognitive screening measures (TICS -- score of 30 or above, and MoCa -- score of 22 and above)
no indication of serious psychiatric disturbance including current major depression
disease
willing and able to give informed consent
age 55-100 years of age
generally physically and neurologically healthy as determined by the Health
Demographics Screener
native English speaker
at least 8th grade education
no indication of dementia based on score of 30 or above on the Telephone Interview for
Cognitive Status and nonimpaired score on the Montreal Cognitive Assessment (MoCA --
eligible for MRI as determined by the MRI Eligibility Interview
score of 22 and above)
no indication of serious psychiatric disturbance including current major depression
(based on Mental Health Screener)
willing and able to give informed consent
community-dwelling with subjective report of cognitive complaints with scores >16 on
the Cognitive Change Index (CCI-20)
no evidence of dementia or mild cognitive impairment based on cognitive screening
using the MoCA; scores must fall within normal limits for age, education, and sex
score of 0 on the Global Clinic Dementia Rating (CDR) scale
no psychometric evidence of neuropsychological impairment on a modified
Neuropsychological Battery from the NACC Unified Data Set, version 3
normal functional behavior in terms of daily activities, based on the Functional
Activities Scale (FAQ)
availability of an informant (over the phone) who can provide information about the
participant's complaints using the informant version of the CCI-20, and corroborate
normal activities of daily living on the FAQ and the CDR scale

Exclusion Criteria

Pregnant or possibly pregnant
Claustrophobia
Large pieces of metal in the body, particularly in the face and neck
Piercings or metal implants that cannot be removed from the body
Surgery on the brain or any prior serious brain damage or disease
Dementia or severe cognitive disorders
use of prescribed 'memory enhancing' medications such as Aricept or Namenda
use of antipsychotics, sedatives, or other medications with significant
anticholinergic properties (due to potential influence on memory)
Clear my responses

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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