Emotion Study/Substudy: Flexible Brain Study

STATUS

Recruiting
End date

Dec 30, 2022
participants needed

226
sponsor

University of Florida

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Updated on 30 June 2022

See if I qualify

depression

cognitive impairment

dementia

alzheimer's disease

parkinson's disease

tics

mild cognitive impairment

Accepts healthy volunteers

Summary

The proposed research applies the highly innovative technology of real-time functional Magnetic Resonance Imaging (rtfMRI) to examine plasticity of brain-regulatory mechanisms related to cognitive and affective processing and to determine benefits for cognition and affect in young and older adults and in Parkinson Disease (PD) patients.

Description

There is increasing evidence that age-related alterations in brain function associated with affective processing and attention contribute to these motivational and emotional changes with age.

Based on these theoretical considerations as well as the previous study's data, the proposed research will apply well-tested emotion processing and attention paradigms to address the pivotal question of whether brain activity can be modulated in healthy aging and PD (in the substudy) via contingent rt-fMRI neurofeedback and whether this neuroregulatory modulation increases emotion processing and cognitive performance.

Details

Condition	Aging, Emotions, Parkinson Disease
Treatment	Anterior cingulate cortex activation, Primary auditory cortex activation
Clinical Study Identifier	NCT03872414
Sponsor	University of Florida
Last Modified on	30 June 2022

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Young adults
	aged 18-35 years of age
	native English speaker
	at least 8th grade education
	eligible for MRI as determined by the MRI Eligibility Interview (including not being pregnant)
	scores within normal limits on a cognitive screener (MoCA)
	no indication of serious psychiatric disturbance including major depression (based on Mental Health Screener)
	willing and able to give informed consent
	Inclusion Criteria: Older adults
	age 55-100 years of age
	native English speaker
	at least 8th grade education
	eligible for MRI as determined by the MRI Eligibility Interview
	willing and able to give informed consent
	Inclusion Criteria: Parkinson patients
	must meet criteria for diagnosis of idiopathic Parkinson disease according the UK Brain Bank by a movement trained neurologist
	age 55-100 years of age
	native English speaker
	at least 8th grade education
	generally physically and neurologically healthy other than Parkinson disease
	eligible for MRI as determined by the MRI Eligibility Interview
	Inclusion Criteria: Individuals with SCD and a family history of dementia or Alzheimer's
	no indication of dementia based on cognitive screening measures (TICS -- score of 30 or above, and MoCa -- score of 22 and above)
	no indication of serious psychiatric disturbance including current major depression
	disease
	willing and able to give informed consent
	age 55-100 years of age
	generally physically and neurologically healthy as determined by the Health
	Demographics Screener
	native English speaker
	at least 8th grade education
	no indication of dementia based on score of 30 or above on the Telephone Interview for
	Cognitive Status and nonimpaired score on the Montreal Cognitive Assessment (MoCA --
	eligible for MRI as determined by the MRI Eligibility Interview
	score of 22 and above)
	no indication of serious psychiatric disturbance including current major depression
	(based on Mental Health Screener)
	willing and able to give informed consent
	community-dwelling with subjective report of cognitive complaints with scores >16 on
	the Cognitive Change Index (CCI-20)
	no evidence of dementia or mild cognitive impairment based on cognitive screening
	using the MoCA; scores must fall within normal limits for age, education, and sex
	score of 0 on the Global Clinic Dementia Rating (CDR) scale
	no psychometric evidence of neuropsychological impairment on a modified
	Neuropsychological Battery from the NACC Unified Data Set, version 3
	normal functional behavior in terms of daily activities, based on the Functional
	Activities Scale (FAQ)
	availability of an informant (over the phone) who can provide information about the
	participant's complaints using the informant version of the CCI-20, and corroborate
	normal activities of daily living on the FAQ and the CDR scale
Exclusion Criteria
	Pregnant or possibly pregnant
	Claustrophobia
	Large pieces of metal in the body, particularly in the face and neck
	Piercings or metal implants that cannot be removed from the body
	Surgery on the brain or any prior serious brain damage or disease
	Dementia or severe cognitive disorders
	use of prescribed 'memory enhancing' medications such as Aricept or Namenda
	use of antipsychotics, sedatives, or other medications with significant
	anticholinergic properties (due to potential influence on memory)

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Study Definition

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Emotion Study/Substudy: Flexible Brain Study