Microglial Cells Activation Imaging Using PET-CT With 18F-DPA714

  • STATUS
    Recruiting
  • End date
    Nov 1, 2024
  • participants needed
    500
  • sponsor
    Weibing Miao, PhD
Updated on 18 February 2022
Accepts healthy volunteers

Summary

There is accumulating evidence suggesting that inflammatory processes, through microglial activation, would play a key role in brain injury and degeneration. It is considered that microglial activation would be part of self-propelling cycle of neuroinflammation that fuels Neurologic deterioration. It is however hard to evidence microglial activation in vivo: first, the investigators need very high-resolution imaging tools and then, the only ligand available to date, 11C-PK11195, has a low sensitivity and specificity and provided heterogeneous results. 18F-DPA-714 is a new PET ligand which labels microglial cells. The investigators aim to explore the clinical feasibility used PET-CT with 18F-DPA714 to monitor microglial cells activation of brain in several different disease. This study might reveal significant neuroinflammatory process in the brain. The results of this study might provide a new biomarker of disease pathological progression and help as identifying subjects who might most benefit from a specific anti-inflammatory drug.

Details
Condition Microglial Cells Activation Imaging
Clinical Study IdentifierNCT04171882
SponsorWeibing Miao, PhD
Last Modified on18 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age > 18 years
Positron emission tomography scans were acquired more than twice
Written informed consent was provided by the patients and their health care proxies -

Exclusion Criteria

Contraindication for PET examination
Clear my responses

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