An Open-Label, Phase I Study to Evaluate the Safety, Pharmacokinetics and Preliminary Antitumor Activity of RO7227166 (a CD19 Targeted 4-1BB Ligand) in Combination With Obinutuzumab and in Combination With Glofitamab Following a Pre-Treatment Dose of Obinutuzumab Administered in Participants With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

  • participants needed
  • sponsor
    Hoffmann-La Roche
Updated on 30 January 2023
ct scan
hodgkin's disease
b-cell lymphoma
non-hodgkin's lymphoma refractory


This is a phase I/II, open-label, dose-escalation study designed to evaluate the safety, tolerability, and efficacy of RO7227166 in participants with relapsed/refractory Non-Hodgkin's Lymphoma (r/r NHL). RO7227166 will be administered by intravenous (IV) infusion in combination with obinutuzumab and in combination with glofitamab. A fixed dose of obinutuzumab (Gpt; pre-treatment) will be administered seven days prior to the first administration of RO7227166 and seven days prior to the first administration of glofitamab. This entry-into-human study is divided into a dose-escalation stage (Part I and Part II) and a dose expansion stage (Part III).

Condition Lymphoma, Non-Hodgkin
Treatment Tocilizumab, Obinutuzumab, RO7082859, RO7227166, Glofitamab
Clinical Study IdentifierNCT04077723
SponsorHoffmann-La Roche
Last Modified on30 January 2023

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