This is a phase I/II, open-label, dose-escalation study designed to evaluate the safety, tolerability, and efficacy of RO7227166 in participants with relapsed/refractory Non-Hodgkin's Lymphoma (r/r NHL). RO7227166 will be administered by intravenous (IV) infusion in combination with obinutuzumab and in combination with glofitamab. A fixed dose of obinutuzumab (Gpt; pre-treatment) will be administered seven days prior to the first administration of RO7227166 and seven days prior to the first administration of glofitamab. This entry-into-human study is divided into a dose-escalation stage (Part I and Part II) and a dose expansion stage (Part III).
| Condition | Lymphoma, Non-Hodgkin |
|---|---|
| Treatment | Tocilizumab, Obinutuzumab, RO7082859, RO7227166, Glofitamab |
| Clinical Study Identifier | NCT04077723 |
| Sponsor | Hoffmann-La Roche |
| Last Modified on | 30 January 2023 |
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