Transplanting Hepatitis C Lungs Into Negative Lung Recipients
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- STATUS
- Recruiting
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- End date
- Dec 31, 2021
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- participants needed
- 10
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- sponsor
- University of Pennsylvania
Summary
This study is being conducted to determine safety and effectiveness of transplanting lungs from Hepatitis C-positive donors into Hepatitis C-negative patients on the lung transplant waitlist, who will then be treated with appropriate direct-acting antiviral (DAA) after transplantation.
Description
Open-labelled pilot clinical trial of Zepatier (Grazoprevir + Elbasvir), Epclusa (Sofosbuvir + Velpatasvir), or another appropriate DAA in at least 10 HCV-negative subjects receiving a lung transplant from a hepatitis C (HCV)-positive donor. Eligible subjects will receive a lung transplant from a deceased-donor, and then will receive treatment after lung transplantation when infection with HCV is confirmed in these lung transplant recipients. Treatment will be complete after 12 weeks for most subjects.
Details
| Condition | Pulmonary Disease, Lung Disease, pulmonary diseases, lung diseases, pulmonary disorders |
|---|---|
| Treatment | Zepatier, Epclusa |
| Clinical Study Identifier | NCT03724149 |
| Sponsor | University of Pennsylvania |
| Last Modified on | 24 January 2021 |
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