Bisphenol A and Muscle Insulin Sensitivity

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    40
  • sponsor
    California Polytechnic State University-San Luis Obispo
Updated on 17 February 2022
Accepts healthy volunteers

Summary

This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.

Description

Evidence linking bisphenol A exposure with diabetes risk remains mainly associative in nature, and mechanism linking bisphenol A to type 2 diabetes remains unclear. The investigator's preliminary data suggests that in young adults, single oral BPA consumption significantly decreased glucose, insulin, and C-Peptide responses to an oral glucose tolerance test, suggesting that immediate consumption of bisphenol A has an effect on muscle insulin sensitivity, hepatic glucose suppression and/or digestion and absorption to lower blood glucose, insulin, and C-Peptide concentrations. The present experimental study evaluating the effects of bisphenol A over several days on the pathogenesis of type 2 diabetes will directly assess each of these potential mechanisms using gold standard measures (euglycemic hyperinsulinemic clamp technique and hepatic glucose suppression with glucose stable isotope infusion, and fecal microbiota).

Details
Condition Insulin Sensitivity, Glucose Metabolism Disorders, Microtia
Treatment Placebo, bisphenol A
Clinical Study IdentifierNCT03771066
SponsorCalifornia Polytechnic State University-San Luis Obispo
Last Modified on17 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

non-dieting
sedentary (3 hour/week of aerobic exercise)
normal-weight (BMI = 18.5 to 24.9 kg/m2)
weight-stable for the previous 6 months
free of any metabolic or chronic disease
non-smoking, and sedentary

Exclusion Criteria

Hemoglobin A1C based on the American Diabetes Association guidelines of 5.7 to 6.4% (Prediabetes) or >6.4% (Diabetes)
impaired glucose tolerance
type 1 diabetes
type 2 diabetes
colitis or any inflammatory bowel condition
neurologic or psychiatric conditions
smoking
special diets (e.g. vegetarian, low-carbohydrate, Paleolithic, etc.)
pregnant women or women trying to become pregnant
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