Bisphenol A and Muscle Insulin Sensitivity

  • participants needed
  • sponsor
    California Polytechnic State University-San Luis Obispo
Updated on 4 February 2023
Accepts healthy volunteers


This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.


Evidence linking bisphenol A exposure with diabetes risk remains mainly associative in nature, and mechanism linking bisphenol A to type 2 diabetes remains unclear. The investigator's preliminary data suggests that in young adults, single oral BPA consumption significantly decreased glucose, insulin, and C-Peptide responses to an oral glucose tolerance test, suggesting that immediate consumption of bisphenol A has an effect on muscle insulin sensitivity, hepatic glucose suppression and/or digestion and absorption to lower blood glucose, insulin, and C-Peptide concentrations. The present experimental study evaluating the effects of bisphenol A over several days on the pathogenesis of type 2 diabetes will directly assess each of these potential mechanisms using gold standard measures (euglycemic hyperinsulinemic clamp technique and hepatic glucose suppression with glucose stable isotope infusion, and fecal microbiota).

Condition Insulin Sensitivity, Glucose Metabolism Disorders, Microtia
Treatment Placebo, bisphenol A
Clinical Study IdentifierNCT03771066
SponsorCalifornia Polytechnic State University-San Luis Obispo
Last Modified on4 February 2023

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