Identification of Genetic Causes of Calcific Aortic Valve Disease

  • End date
    Jun 30, 2027
  • participants needed
  • sponsor
    Beth Israel Deaconess Medical Center
Updated on 4 October 2022
aortic surgery
aortic disease
aortic valve replacement
aortic valve disease
Accepts healthy volunteers


This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.

Condition Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification, Aortic Diseases, Aortic Aneurysm, Aortic Valve Cusp Abnormality, Aortic Valve Disease Mixed, Aortic Valve Insufficiency
Treatment Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.
Clinical Study IdentifierNCT04149600
SponsorBeth Israel Deaconess Medical Center
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Patients with a plan to undergo elective aortic valve replacement and/or ascending aortic surgery

Exclusion Criteria

Age < 20 years
Unable/unwilling to consent
History of aortic valve replacement or transcatheter aortic valve replacement (TAVR)
History of endocarditis
History of rheumatic fever
History of chest radiotherapy
History of organ transplant
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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