Last updated on November 2019

Treatment of Patients With Atherosclerotic Disease With Paclitaxel-associated to LDL Like Nanoparticles


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Inflammation | Atherosclerosis | Coronary heart disease | Coronary Artery Disease
  • Age: Between 18 - 80 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Multi-vessels coronary artery disease diagnosis by coronary CTA scan or invasive angiography
  • Aortic atherosclerosis diagnosis by multidetector computed tomography (MDCT) angiography.
  • Signing the study informed consent.

Exclusion Criteria:

  • History of AMI in the last 30 days
  • Heart failure with ejection fraction <40%
  • Estimated glomerular filtration rate < 40 mL/min/1.73 m2.
  • Prior history of chronic infectious disease, including tuberculosis, severe fungal disease, or known HIV positive.
  • Chronic hepatitis B or C infection.
  • Prior history of nonbasal cell malignancy or myeloproliferative or lymphoproliferative disease within the past 5 years.
  • White blood cell count <4000/mm3, hematocrit <32%, or platelet count <75000/mm3.
  • Alanine aminotransferase levels (ALT) greater than 3-fold the upper limit of normal.
  • History of actual alcohol abuse or unwillingness to limit alcohol consumption to < 4 drinks per week.
  • Pregnancy or breastfeeding.
  • Women of child bearing potential, even if currently using contraception.
  • Men who plan to father children during the study period or who are unwilling to use contraception.
  • Chronic use of oral steroid therapy or other immunosuppressive or biologic response modifiers.
  • Known chronic pericardial effusion, pleural effusion, or ascites.
  • Angina pectoris CCS III-IV
  • New York Heart Association class III-IV congestive heart failure.
  • Contraindication for the use of iodinated contrast
  • Life expectancy of < 1 years.
  • Acute or Chronic aortic dissection

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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