Conservative Endometrioma Surgery (BLAST)

  • End date
    Mar 13, 2025
  • participants needed
  • sponsor
    Universitaire Ziekenhuizen Leuven
Updated on 13 July 2022
anti-mullerian hormone


To study which surgical technique offers better results in treating endometriomas in terms of ovarian reserve preservation.

The 2 conservatives techniques used are:

  1. The combined technique
  2. CO2 laser vaporization only

Ovarian reserve will be assessed by consecutive measurements of AMH serum levels before and after surgery.

Condition Endometriosis Ovary, Endometrioma
Treatment Comparison between 2 different laparoscopic techniques in conservative surgical treatment of endometriomas (both arms are existing and accepted surgical strategies).
Clinical Study IdentifierNCT04151433
SponsorUniversitaire Ziekenhuizen Leuven
Last Modified on13 July 2022


Yes No Not Sure

Inclusion Criteria

Age: 18 - 40 years (both inclusive)
Unilateral endometriotic cysts with a mean diameter of >=2.5cm and ≤8 cm, measured in 3 dimensions
Presence of a contralateral endometrioma of ≤ 2cm is allowed
Complaining of infertility and/or pain
BMI ≤35
Use of contraception (combined or Progesteron only) for at least 4 weeks before surgery

Exclusion Criteria

Incomplete surgery for the pelvis
Contra-indication for the use of contraception (combined or Progesteron only)
Use of GnRH analogues preoperatively and in the first 3 months postoperatively
(History of) hysterectomy
Prior unilateral oophorectomy
Pituitary/hypothalamic disorders
Suspected malignancy
Contralateral endometrioma of >2 cm
AMH <0.7 preoperatively
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