Plasma Ropivacaine Concentrations After Sciatic Nerve Block in Patients With Chronic Kidney Disease

  • STATUS
    Recruiting
  • days left to enroll
    54
  • participants needed
    12
  • sponsor
    Seoul National University Hospital
Updated on 17 February 2022

Summary

This prospective observational study aimed to examine the pharmacokinetics of ropivacaine in patients with chronic kidney disease after sciatic nerve block.

Sciatic nerve block for foot and ankle surgery will be performed using ropivacaine under ultrasound-guidance, and arterial blood test will be taken for total plasma ropivacaine concentration at 2.5, 5, 15, 30, 60 minutes and 2, 6, 24 hours after sciatic nerve block.

Details
Condition Regional Anesthesia Morbidity, Local Anesthetic Drug Adverse Reaction
Treatment sciatic nerve block
Clinical Study IdentifierNCT03666845
SponsorSeoul National University Hospital
Last Modified on17 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients scheduled for foot and ankle surgery
Patients with chronic kidney disease (glomerular filtration rate < 60 ml/min/1.73m2) (changed from 30 ml/min/1.73m2 to facilitate patient recruitment)
Patients who are thought to be clinically helpful to receive sciatic nerve block rather than general anesthesia because of comorbidities such as cardiopulmonary dysfunction and cerebral dysfunction

Exclusion Criteria

Patients who need to renal replacement therapy, such as hemodialysis
Patients with liver disease (aspartate transaminase OR alanine transaminase > 80 IU/L)
Patients with allergic disease
Patients with previous history of drug allery
Patients with chronic pain persisting 3 months
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