Pharmacogenetic Testing of Patients With Unwanted Adverse Drug Reactions or Therapy Failure
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- STATUS
- Recruiting
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- End date
- Oct 1, 2022
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- participants needed
- 100
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- sponsor
- University Hospital, Basel, Switzerland
Summary
Genetic makeup of a patient influences the efficacy and safety profile of a drug. This study is to summarize individual cases, where Pharmacogenetics (PGx) has been applied during pharmaceutical care. The primary objective is the compilation of case reports, where pharmacogenetic testing is applied to determine the hereditable component of the patient's susceptibility to experience therapy failure and/or adverse drug reactions. The experience with the compiled cases will be basis for the development of a reliable standard of procedure for pharmacogenetic testing in the community pharmacy. The cases will be supplemented with information on additional Parameters reported in the literature to affect efficacy or safety of the respective drug.
Description
Genetic makeup of a patient influences the efficacy and safety profile of a drug. This study is to summarize individual cases, where Pharmacogenetics (PGx) has been applied during pharmaceutical care. Health-related data of patients experiencing therapy failure (TF) or adverse drug reaction (ADR) is collected and will then be supplemented with pharmacogenetic testing during pharmaceutical care in a study pharmacy. The patient data (diagnoses, medications and results of pharmacogenetic testing) is harmonized in order to generate a compilation of case reports. The primary objective is the compilation of case reports, where pharmacogenetic testing is applied to determine the hereditable component of the patient's susceptibility to experience therapy failure and/or adverse drug reactions. The experience with the compiled cases will be basis for the development of a reliable standard of procedure for pharmacogenetic testing in the community pharmacy. The cases will be supplemented with information on additional Parameters reported in the literature to affect efficacy or safety of the respective drug.
Details
| Condition | Adverse Drug Reaction, Therapy Failure |
|---|---|
| Treatment | Buccal swab, EDTA Blood sample (4.9mL), Serum sample (7.5mL), communication of test results, unstructured interview |
| Clinical Study Identifier | NCT04154553 |
| Sponsor | University Hospital, Basel, Switzerland |
| Last Modified on | 17 February 2022 |
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