RFA Plus Carrizumab vs Carrizumab Alone for HCC

  • STATUS
    Recruiting
  • End date
    Dec 30, 2026
  • participants needed
    120
  • sponsor
    Second Affiliated Hospital, School of Medicine, Zhejiang University
Updated on 16 February 2022
immunosuppressive agents
carcinoma
liver transplant
hepatocellular carcinoma
Accepts healthy volunteers

Summary

The study aims to find whether patients with advanced HCC can get more benefits from RFA +PD-1 immunosuppressant (carrizumab) compared with carrizumab alone, considering with the result of PFS.

Description

The study aims to find whether patients with advanced HCC can get more benefits from RFA +PD-1 immunosuppressant (carrizumab) compared with carrizumab alone, considering with the result of PFS. 120 patients were enrolled into two groups respectively, the experimental group and reference group.

Details
Condition Tumor Immunity, Immunosuppression, Radiofrequency Ablation
Treatment Radiofrequency ablation
Clinical Study IdentifierNCT04150744
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
Last Modified on16 February 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age from 18-75 years
Diagnosis as hepatocellular carcinoma from histology and cytology
BCLC B-C degree
Score of ECOG PS: 0-2
Child-Pugh Score: A or B
Not suitable for resection or liver transplantation
Have not received systemic therapy
Have at least one evaluable target mass from CT or MRI according to mRECIST
The estimated survival time 12 weeks
Patients with HBV infection having HBV-DNA <500IU/mL and standard anti-virus treatment. Patients with HCV infection must receive standard anti-virus treatment
The function of main organs normal
Sign informed consent

Exclusion Criteria

Have cholangiocarcinoma, mixed type of hepatocarcinoma and fibrolamellar hepatocellular carcinoma. Have incurable malignant tumor in five years
Have local ablation, TACE or radiotherapy in 3 months before enrolled
Prepared to or have received organic or bone marrow transplantation
Uncontrollable ascites, hepatic encephalopathy or esophageal and gastric varices
Have hypertension and can't lower down to the normal level using blood pressure medication
Have type II myocardial ischemia or myocardial infarction, uncontrollable arrhythmia
Have diseases to influent the effect of oral drugs, for example, unable to swallow, chronic diarrhea and intestinal obstruction
Have gastrointestinal bleeding in 6 months
Have abdominal fistula, gastrointestinal perforation or abdominal abscess
Patients with lung fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug related pneumonia or severe dysfunction of lung
Routine urine test showed urinary protein ++ or the 24 hours amount of urinary protein 1.0 g
Patients have autoimmune disease
Patients need corticosteroid or other immunosuppressant therapy
Patients have anti-tumor vaccine and other immunostimulate anti-tumor drugs in 3 months
Allergy to monocloning antibody
Pregnant or breastfeeding female Other patients not suitable to be enrolled in the study
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note